Background: Bell’s palsy is an acute, idiopathic facial nerve paralysis that can significantly impact patients’ physical appearance, communication abilities, and psychological well-being. While spontaneous recovery is possible, structured rehabilitation programs can greatly improve outcomes. Study. Aim: Evaluate the effect of the Rehabilitation Program on knowledge, self-care practices, and quality of life among patients with Bell’s palsy. Design: A quasi-experimental design was used. Setting: Brain and neurologic outpatient clinic and physiotherapy department at Zagazig University Hospitals in the Al Sharkia governorate of Egypt. Subjects: A purposive sample of 48 adult patients with Bell’s palsy in the aforementioned setting. Tools: An interview questionnaire to assess patients' knowledge, a self-care practices observational checklist, and a facial function and quality of life assessment scale. Results: There was a highly statistically significant improvement and difference in overall patients' knowledge and self-care practices in the post-phase of the rehabilitation program compared to the pre-phase (p<0.001), which resulted in improving their facial function and quality of life, as there was a statistically significant positive correlation of facial function and quality of life improvement scores with knowledge and self-care practices through program phases. Conclusion: The rehabilitation program plays an effective role in improving knowledge, self-care practices, and facial function and quality of life for patients with Bell’s palsy and has a positive effect. Recommendations: The developed rehabilitation program should be implemented on a wide scale in study settings and all similar ones, including all governmental hospitals. Key Words: Rehabilitation Program, Knowledge, Self- Care Practices, Quality of Life, Bell’s palsy.