Background: Hypertension is affecting 40.8% of females 38.7% of males in Egypt, and the total is affecting 39.7% of the population. High prevalence of hypertension connected to a wide range of severe medical disorders. Aim: to measure the outcomes of patients' instructions effects about modifiable risk factors for hypertensive patients on their attitude, and lipid profile. Subjects and Methods: A quasi-experimental design with one group pre, post, and follow-up was utilized to achieve the aim of the study. Sample: a convenience sample including 100 adult patients enrolled in this study. Setting: a study was conducted in cardiac and internal medicine outpatient clinics at Zagazig University Hospital and Beni-suef University hospital. Tools: The researchers prepared an interview form including three sections: I- Questionnaire to Patient Interview Questionnaire Sheet include Part 1: Assess patients’ demographic characteristics Part 2: Assess Patient 's family, past and recent medical history, assess the associated chronic disease, medications, allergies and previous source of health knowledge. Part 3: Patient's Physical Assessment and Laboratory Investigation Sheet. II- The lifestyle attitude assessment. Results: the present study showed that more than have of the study sample have 50+years, female ,have work, secondary school , their blood pressure , lipid profile, blood glucose reading decreased at the follow-up with highly statistically significant, marked changes of lifestyle with highly statistically significant difference among study phases in all items except in exercise . also in knowledge, levels , and medical examination, there is Correlation between lipid profile and level of practice, Correlation between lab investigation and level of knowledge. Conclusions: study concluded that personalized, tailored nursing instructions could be adjusted blood pressure through improving hypertensive patients' attitude and normalize lipid profile. Therefore, the confident effect of the program is lifelong. Recommendations: study recommended nursing instructions should apply in various outpatients' cardiac clinics and medical service centers and training of nurses to provide this service. The informative booklet ought to be conveyed to all patients. Keywords: Patients’ instructions, Modifiable Risk factors, Hypertension, Attitude, Lipid profile.