Background: Myocardial infarction is the death of myocardial tissue because of extended lack of blood and oxygen. Clinical pathway has emerged as one of the most famous new initiatives alleged to lower costs whilst maintaining or even improving the satisfactory level of patient care. Aim: to assess the effect of clinical pathway regarding promoting quality Nursing care of patients with MI exposed to invasive procedures through designing, Implementing, and evaluating the effect of clinical pathway intervention. Design: A quasi-experimental research design (pre posttest) changed into applied in this study. This study carried out in Beni-suef university Hospital, Zagazig University Hospitals. Sample: thirty nurses from the previously mentioned setting and thirty patients with myocardial infarction who are hospitalized and ex- posed to invasive procedures. Tools: Assessment questionnaire (pre/post test) sheet, An Observational Checklist, and Hamilton Anxiety Rating Scale (HAM-A). Results: more than fifty percent of a studied sample of nurses their ages ranged from 20-30yrs, the mean age was (29.1±3.4), females (66.9%), and have been trained in nursing college, their work experience ranged from half to one decade. There has been a statistically significant distinction concerning knowledge and practical abilities of studied nurses among pre and post application of clinical pathway. Conclusion: More than fifty percent of a studied sample of nurses have been a statistically significant distinction amongst pre and post clinical pathway application concerning knowledge and practical skills of studied nurses. Also, there has been a statistically significant distinction among the overall level of knowledge of studied nurses and the entire level of their practical skills before and after program application. Recommendations: Extra new studies should be done for better assessment of the nurse's abilities and distribute educational booklets, pamphlets, and posters to all nurses with a purpose to enhance their degree of knowledge and skills. Keywords: Clinical Pathway; Quality Nursing Care; Patients; and Myocardial Infarction.