Abstract Background: The gold standard treatment for end-stage arthritis is total knee arthroplasty, which has a high rate of efficacy and satisfaction among patients. Aim of the study: This study aimed to evaluate nurses' performance regarding discharge plan for patient post total knee arthroplasty. Subjects and methods: Research design: A descriptive research design was used. Setting: This study was conducted at orthopedic department of new surgery hospital at Zagazig University hospitals, Sharqia Governate, Egypt. Subjects: A convenient sample of all available nurses (46 nurses) were selected from the mentioned setting. Tool of data collection: two tools were utilized for data collection: Self-administered questionnaire and observational checklist. Results: Revealed that, less than two thirds (63%) of the studied nurses had unsatisfactory knowledge regarding total knee arthroplasty. More than half (56.5%) had inadequate total practice scores regarding discharge plan of the patient undergoing total knee arthroplasty. Conclusion: there was a highly significant association between overall studied nurses knowledge score and total practice score related to total knee replacement. Recommendation: Improving nurses' education and training so they can carry out efficient discharge planning. Keywords: Discharge Plan, Nurses' performance, Total knee arthroplasty.