English abstract Background: Patient safety measures are directed to prevent or minimize complications and adverse event incident that needs the collaboration of all health staff. Nurses have a significant role in improving patient safety as major personnel dealing continuously over 24 hours with the patients. Aim of the study: Assess nurses' awareness, commitment, and attitudes regarding patient safety measures. Subjects and Method: Research design: A cross-sectional, descriptive design was utilized. . Setting: The study was conducted at Medical-Surgical Units of Zagazig university hospitals. Subject: A convenient sampling of 100 nurses selected from these units from January to March 2021. Tools of data collection: Two tools were used for data collection. Tool (I): A structured interviewing questionnaire that included four parts: demographic characteristics of participants, nurses' awareness, commitment, and attitude's regarding patient safety measures. Tool (II): was perceived implicit rationing of nursing care. Results: the majority of participants were females, less than half didn‘t receive training courses regarding patient safety, more than three quarters reported that safety measures were excellent and had total satisfactory awareness regarding patients safety, nearly to half had high commitment level score, less than two-thirds had total positive attitudes, only half had a satisfactory total safety practices knowledge level score, more than quarter were rating missed nursing care as high and or moderate. Conclusion: Gaining confirmation regarding the level of nurses' awareness, commitment, and attitudes, toward patient safety measures are significant to undertake the essential strategies required to minimize the burden of health care, and its related effects. Recommendations: Continuously training on patient safety measures must be provided to nurses to be proficient, devoted, updating regarding patients' safety measures. Keywords: Awareness, Commitment, Attitudes, Patients, Safety Measures