English abstract Background: The most prevalent corneal ectatic condition is keratoconus (KC). It is characterized by a thin, cone shaped cornea that causes myopia, uneven astigmatism, and visual impairment. The Aim of this study: was to evaluate vision-related quality of life in keratoconus patients at Zagazig University Hospitals. Research Design: In this study, a descriptive design was adopted. Setting: The research was carried out in the Zagazig University Hospitals' Ophthalmology Outpatient Clinics. Tool of data collection and subjects: A self-administered questionnaire based on the National Eye Institute Visual Functioning Questionnaire – 25 (VFQ-25) was used to measure the visual functioning of 54 male and female patients. Results: The findings revealed that 42.6 percent of the sample were between the ages of 31 and 40 years, that almost three-fifths of the research sample (59.3%) were male and employees, that 63 percent were married, and that 83.3 percent were nonsmokers. Conclusion: The study concluded that Keratoconus has a negative effect on the majority of patients’ vision-related quality of life. Recommendations: It was suggested that all nurses be trained on effective intervention for patients with keratoconus in order to improve their eyesight standard of living. Keywords: Vision-related quality of life, Keratoconus, Patients.