English abstract The nurses, as members of the medical team, are considered the first line of defense against Coronavirus (COVID-19). They are in direct contact with infected cases for long hours and exposed to psychological distress, occupational burnout, and physical violence. There is a paucity of literature on the study of nurses' performance toward the pandemic COVID-19. Thus, the present study was aimed to assess the performance and attitudes of nurses toward infected and deceased cases with Coronavirus. A cross-sectional descriptive study was conducted in three quarantine hospitals in Zagazig city, among 289 male and female nurses using a self- administered questionnaire to assess their Knowledge, Attitudes, and Practices (KAPs). Consequently, collected data was coded, analyzed using SPSS version 20 with various statistical models to find the significance of data and achieve the aim of the study. The results showed that the majority of nurses have correct knowledge except for Emergency' nurses with a mean score of 47.0±3.79, an absolute majority of nurses had good preventive practices, especially in ICU with a mean score of 24.68 ± 2.28. Moreover, a positive statistical relationship was found between total knowledge score, preventive practices, and attitudes (P<0.001). The study concluded that the majority of nurses' knowledge was correct and their preventive practices were good. We recommended continuous provision of training of all nurses on proper infection preventive measures with a focus on emergency' nurses Keywords: Attitude, Coronavirus, COVID-19, Cross-sectional, Deceased Case, Infections, Pandemics, Questionnaires, Quarantine