Background: Patients with cardiothoracic surgery are exposed to a wide range of pain following tissue injury associated with surgery, so adequate pain control is a substantial factor in improving patients' outcomes. Non-pharmacological measures are an important part of pain management that used by critical care nurses to increase the tolerance of experienced pain, decrease physical stress, reduce the feeling of weakness, and reduce the use of analgesics. Aim of the study: was to assess nurses’ practices regarding non-pharmacological pain management for patients with cardiothoracic surgery at Zagazig University Hospitals. Subjects and Methods: Research design: descriptive exploratory design was used. Setting: The study was conducted in the postoperative cardiothoracic surgery department at Zagazig University Hospitals. Subjects: Convenient sample of all available nurses (55) working in cardiothoracic surgery wards and open heart ICU at Zagazig University Hospitals. Tools of data collection: An interview questionnaire and observational checklist were used to collect data. Results: Studied nurses' age ranged between 22-50 years old, 96.4% of them were females, 63.6% of studied nurses had a technical institute degree in nursing science, and 61.8% of studied nurses didn’t attend previous training courses about nonpharmacological pain management. Furthermore, 67.3% had unsatisfactory total practice regarding non-pharmacological pain management. There was a positive statistically significant correlation of total practice score with nurses’ age, and nurses’ experience years in the nursing field and at the cardiothoracic surgery departments. Conclusion: Nurses had an unsatisfactory level practice regarding non-pharmacological pain management. Recommendations: Workshops are highly recommended to improve nursing practices regarding pain assessment and non-pharmacological pain management for patients with cardiothoracic surgery.