Abstract Background: Sudden cardiac death is one of the most common reasons of death worldwide which is prevented by inserting a pacemaker. Pacemaker is an electronic device that placed under the skin of the chest to help control abnormal heart rhythms by conducts electrical stimuli to the heart muscle. Aim of the study: To assess nurses' role regarding the care of patients with permanent pacemaker. Subjects and Methods: Research design: A descriptive exploratory design was utilized. Setting: The study was conducted in all cardiac care units at Zagazig University Hospitals Subjects: A convenient sample of all available nurses (60). Tools of data collection: Two tools were used to collect the study data: Selfadministered questionnaire about personal characteristics of study nurses and nurses` knowledge. An observational checklist to assess nurses` practice. Results: Four fifth (80.0%) of the studied nurses had unsatisfactory level of total knowledge regarding care of patients with permanent pacemaker. The most (90.0%) of studied nurses had unsatisfactory level of total practice regarding care for patients with permanent pacemaker. Conclusion: Most of studied nurses had unsatisfactory level of performance (knowledge and practice) regarding care of patients with permanent pacemaker .There was statistically significant relation between total nurses' knowledge and practice regarding care of patients with permanent pacemaker . Recommendation: The training programs are highly recommended to improve nurse's knowledge and practice regarding the care of patients with permanent pacemaker. Keywords: Nurses Role, Permanent Pacemaker, Patients Care.