Abstract: Hepatocellular carcinoma (HCC) is the most prevalent type of cancer in Egypt. For individuals with early-stage hepatocellular carcinoma, Radiofrequency ablation (RFA) is a safe and efficient initial-line therapy (HCC). Aim: The purpose of this study was to evaluate the effect of nursing strategies on the performance and satisfaction of Patients with Hepatocellular Carcinoma Undergoing Radiofrequency Ablation Therapy. Design: A quasi-experimental research design was taken. Setting: Interventional Radiology and Arterial Catheterization Center of the New Surgical hospital and the Internal Medicine Outpatient Clinic affiliated to Zagazig University Hospitals in Egypt served as the study's location. Sample: A purposeful sample of 60 hepatocellular carcinoma patients, 30 of whom were randomly allocated to each group study and control groups. Tools: 1) Patients' interview questionnaire (pre/post-tests) to assess socio-demographic data, medical data and patients’ knowledge, practice, and 2) Patient Satisfaction questionnaire (post-test). Results: Majority (86.7%) of patients in study group had satisfactory level of practice post nursing strategies, while nearly more than one fifth (23.3%) of patients in control group had satisfactory level of practice post nursing strategies. Most (93.3 %) of patients in the study group had satisfactory level of satisfaction post implementation of nursing strategies, there were statistically significant differences between the study and control groups regarding their knowledge about RFA therapy and their practice post nursing strategies. Additionally, there are statistically significant differences of study group patients' satisfaction post nursing strategies. Conclusion: Application of nursing strategies for hepatocellular carcinoma patients receiving RFA therapy improved patients' knowledge, practice, and satisfaction in a statistically significant manner, supporting the stated hypothesis. Recommendations: It is important to hold more training sessions on radiofrequency ablation therapy for patients on a wide range of subjects for confirmation of findings and usability issues. Key words: Hepatocellular Carcinoma, Nursing Strategies, Performance, Radiofrequency Ablation Therapy, Satisfaction.