Abstract: Hemodynamic monitoring of a surgical patient acquires a major relevance in high-risk patients and those suffering from surgical diseases associated with hemodynamic instability. So International and national job duties of ICU nurses obligate them to tackle the hemodynamic monitoring. This study aimed to evaluate nurses' knowledge and practice regarding hemodynamic monitoring for patients with cardiothoracic, vascular surgery and patient outcome in cardiothoracic intensive care units at Zagazig University Hospital and Al Ahrar Hospital. A descriptive cross sectional design was utilized. Data were collected from two setting; the cardiothoracic intensive care units at Zagazig University and Al-Ahrar Hospital. The study was conducted on forty four nurses and forty four patients from the same hospital setting which have been selected to the study. Two tools were used for collection of data, first, questionnaire self-administer tool to collect demographic characteristics of study nurses, questions to assess nurses' knowledge regarding hemodynamic monitoring for patients with cardiothoracic, vascular surgery and patient outcome. Second tool was an observational checklist to assess nurses' practice regarding hemodynamic monitoring for patients with cardiothoracic, vascular surgery. Results of this study showed that, more than half of the nurses were less than 30 years and had less than 10 years of experience, half of the nurses graduated from technical institute. Less than a quarter of the studied nurses had satisfactory total knowledge regarding hemodynamic monitoring. Less than one third of the studied nurses had total satisfactory practice regarding hemodynamic monitoring for patients with cardiothoracic, vascular surgery. Relation's analysis showed no significant relation between total nurses’ knowledge and practice scores. There was no significant relation between total knowledge score and total practice score and patient outcome. Conclusion nurses had unsatisfactory level of knowledge and practice about hemodynamic monitoring for patients with cardiothoracic, vascular surgery. They did not apply the most recommended nursing practices regarding hemodynamic monitoring for patients with cardiothoracic, vascular surgery. It is recommended to design and apply training programs to improve nurses' knowledge and practice regarding hemodynamic monitoring for patients with cardiothoracic, vascular surgery. Key words: Hemodynamic Monitoring. Nurses. Cardiothoracic. Vascular. Knowledge. Practice. Patient outcome.