Chronic obstructive pulmonary disease (COPD) industriously influences the quality of life (QoL) with impairment of the physiological, psychosocial functions.Aim of the study: This study aimed to evaluate the effect of supportive nursing care on symptoms severity and QoL for patients with COPD. Subjects and Methods: Research design:a quasi-experimental design was used. Setting: The study was conducted at Chest Department and Chest Outpatient Clinicat Zagazig University HospitalsSubjectsa purposive sample of Forty five patients with COPD were included in this study Tools of data collection: Patients’ assessment questionnaire, Patients’ observational checklists, COPD symptoms severity assessment scale, and the St George's quality of life respiratory questionnaire. Results:There were a lack in patients’ knowledge, practice and QoL regarding COPD pre intervention, which increased in post and follow-up phases of intervention, with a statistically significant difference. Moreover, there was increase in COPD patients’ symptoms severity before intervention, which decreased in post and follow-up phases, with a statistically significance difference.Conclusion: Patients with COPD who received supportive nursing care reported a reduction in symptoms severity and an improvement in QOL. Recommendations: Supportive nursing care should be implemented on a regular basis to improve COPD patients' knowledge, practice, and symptoms severity. Supportive nursing care training programs for nurses caring for COPD patients should be maintained.