Background: Stroke is a significant health problem in developing countries including Egypt. Nursing performance during the golden hours of stroke patient care is critical. Aim of the study: to evaluate the effect of an educational program on nurses' performance regarding patients with cerebrovascular stroke in intensive care units at Zagazig University Hospitals. Subjects and methods: This quasi-experimental study with pre-post ‎assessment was conducted at Zagazig University Hospitals on a sample of 80 nurses.‎ Data were collected using a self-administered questionnaire for knowledge and an observation checklist for practice. The fieldwork was carried out though assessment, planning, implementation, and evaluation phases. Results: Nurses’ age ranged from 23 to 54 years, with more females (68.8%), carrying a diploma in nursing (77.5%). Only 56.3% had satisfactory pre-intervention knowledge, which increased to 100.0% at post and follow-up phases (p<0.001). Also, and 46.3% adequate pre-intervention practice, which increased to 73.8% and 91.3% at the post and follow-up phases respectively (p<0.001). The study intervention was the main positive predictor of nurses’ knowledge and practice scores. Conclusion and recommendations: The implementation of a training program based on their identified needs is effective in improving nurses’ knowledge and practice. The study recommends implementing the developed program on a wide scale in ‎the study settings and in similar ones. Further research is proposed to assess ‎the impact of the educational training ‎program for staff nurses caring of patients ‎with CVS on quality of ‎life of these patients.