The thorough examination of animal carcasses and organs intended for human consumption is crucial for food safety. However, it is not always conducted adequately due to time constraints during the slaughter process. A cross-sectional study was undertaken to identify the key reasons for the rejection of edible offal in slaughtered animals at El-Qurein slaughterhouse in Sharkia Province, Egypt, and to evaluate the associated economic losses during the period from August 2020 to July 2021. The study examined 1,218 organs, including 406 livers, 406 lungs, and 406 hearts, from various animals such as cattle, buffaloes, camels, sheep, and goats. Among these, 138 organs, including 78 livers, 38 lungs, and 22 hearts, were rejected, primarily due to lesions caused by Cysticercus ovis, fascioliasis, Cysticercus tenuicollis, pneumonia, and hydatid cysts. The financial loss at the slaughterhouse resulting from organ rejection over the twelve-month period totaled 1,113,905.24 Egyptian pounds, equivalent to 71,865 USD. The high frequency of meat rejection and the resulting financial impact exceeded the local revenue of the region. This study highlights the persistent prevalence of parasitic diseases, which result in significant detrimental economic repercussions in Sharkia Province, Egypt. Furthermore, the present work underscores the necessity for the development of an effective control program to address the causes of meat rejection in the region.