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GC-MS Analysis and Microbiological Evaluation of Caraway Essential Oil as a Virulence Attenuating Agent against Pseudomonas aeruginosa
Faculty
Pharmacy
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Galal Yehya Abdelreheem Metwally
Staff Zu Site
Abstract In Staff Site
Journal:
Molecules MDPI
Volume:
Keywords :
GC-MS Analysis , Microbiological Evaluation , Caraway Essential
Abstract:
The emergence of resistant microbes threatens public health on our planet, and the emergence of resistant bacteria against the most commonly used antibiotics necessitates urgent alternative therapeutic options. One way to fight resistant microbes is to design new antimicrobial agents, however, this approach takes decades of research. An alternative or parallel approach is to target the virulence of bacteria with natural or synthetic agents. Active constituents from medicinal plants represent a wide library to screen for natural anti-virulence agents. Caraway is used as a traditional spice and in some medicinal applications such as carminative, antispasmodic, appetizer, and expectorant. Caraway essential oil is rich in terpenes that were previously reported to have antimicrobial activities. In our study, we tested the caraway essential oil in sub-inhibitory concentration as a virulence agent against the Gram-negative bacteria Pseudomonas aeruginosa. Caraway essential oil in sub-inhibitory concentration dramatically blocked protease activity, pyocyanin production, biofilm formation, and quorum sensing activity of P. aeruginosa. The gas chromatography–mass spectroscopy (GC-MS) profile of caraway fruit oil identified 13 compounds representing 85.4% of the total oil components with carvone and sylvestrene as the main constituents. In conclusion, caraway essential oil is a promising virulence-attenuating agent that can be used against topical infections caused by P. aeruginosa.
Author Related Publications
Galal Yehya Abdelreheem Metwally, "In-silico screening of naturally derived phytochemicals against SARS-CoV Main protease", Springer- Nature, 2021
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Galal Yehya Abdelreheem Metwally, "Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics", MDPI, 2021
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Galal Yehya Abdelreheem Metwally, "In silico screening of potent inhibitors against COVID-19 key targets from a library of FDA-approved drugs", Springer- Nature, 2021
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Department Related Publications
Mona Abdelmoniem Elsayed Mahmmoud , "The value of peritoneal lavage in peritonitis", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Chemoantibiotic _ resistance in enteropathogenic Escherichia Coli Locally ", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Identification of different Candidia species according to its fatty acids contents.", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "The effects of various antimicrobial agents against Escherichia coli isolated from urine.", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Isolation and Characterization of cellulose from Streptomyces roseoflavus ", لايوجد, 1900
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