Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
In-silico screening of naturally derived phytochemicals against SARS-CoV Main protease
Faculty
Pharmacy
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Galal Yehya Abdelreheem Metwally
Staff Zu Site
Abstract In Staff Site
Journal:
Environmental Science and Pollution Research Springer- Nature
Volume:
Keywords :
In-silico screening , naturally derived phytochemicals against
Abstract:
Coronavirus disease 2019 (COVID-19) is a rapidly growing pandemic that requires urgent therapeutic intervention. Finding potential anti COVID-19 drugs aside from approved vaccines is progressively going on. The chemically diverse natural products represent valuable sources for drug leads. In this study, we aimed to find out safe and effective COVID-19 protease inhibitors from a library of natural products which share the main nucleus/skeleton of FDA-approved drugs that were employed in COVID-19 treatment guidelines or repurposed by previous studies. Our library was subjected to virtual screening against SARS-CoV Main protease (Mpro) using Molecular Operating Environment (MOE) software. Twenty-two out of those natural candidates showed higher binding scores compared to their analogues. We repurpose these natural products including alkaloids, glucosinolates, and phenolics as potential platforms for the development of anti-SARS-CoV-2 therapeutics. This study paves the way towards discovering a lead used in the treatment of COVID-19 from natural sources and introduces phytomedicines with dual therapeutic effects against COVID-19 besides their original pharmacological effects. We recommend further in vitro evaluation of their anti-COVID-19 activity and future clinical studies.
Author Related Publications
Galal Yehya Abdelreheem Metwally, "Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview", MDPI, 2021
More
Galal Yehya Abdelreheem Metwally, "Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats", Springer- Nature, 2021
More
Galal Yehya Abdelreheem Metwally, "Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics", MDPI, 2021
More
Galal Yehya Abdelreheem Metwally, "In silico screening of potent inhibitors against COVID-19 key targets from a library of FDA-approved drugs", Springer- Nature, 2021
More
Galal Yehya Abdelreheem Metwally, "Stress granules display bistable dynamics modulated by Cdk", Rockefeller University Press, 2021
More
Department Related Publications
Eman Mahmoud Hassan Elmasry, "Studies on Chemoantibiotics Resistant patterns linked to Bacteriocin Production in Clinical Isolates of Gram -Negative Rods .", لايوجد, 1900
More
Hassan Ahmed Abdelsalam Mohamed Badr, "Production of Aflatoxins by Immobilized Aspergillus flavus", لايوجد, 1900
More
Mona Abdelmoniem Elsayed Mahmmoud , "The value of peritoneal lavage in peritonitis", لايوجد, 1900
More
Mona Abdelmoniem Elsayed Mahmmoud , "Effects of certain volatile oils on aflatoxins production by Aspergillus species locally isolated", لايوجد, 1900
More
Mona Abdelmoniem Elsayed Mahmmoud , "Effects of some quinolones in adhesiom , haemagglutination , outer membrane proteins and plasmid prophile of uropathogenic Escherichia coli ", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف