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Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
Faculty
Pharmacy
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Galal Yehya Abdelreheem Metwally
Staff Zu Site
Abstract In Staff Site
Journal:
Vaccines MDPI
Volume:
Keywords :
Coronavirus Disease (COVID-19) Control between Drug
Abstract:
Respiratory viruses represent a major public health concern, as they are highly mutated, resulting in new strains emerging with high pathogenicity. Currently, the world is suffering from the newly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is the cause of coronavirus disease 2019 (COVID-19), a mild-to-severe respiratory tract infection with frequent ability to give rise to fatal pneumonia in humans. The overwhelming outbreak of SARS-CoV-2 continues to unfold all over the world, urging scientists to put an end to this global pandemic through biological and pharmaceutical interventions. Currently, there is no specific treatment option that is capable of COVID-19 pandemic eradication, so several repurposed drugs and newly conditionally approved vaccines are in use and heavily applied to control the COVID-19 pandemic. The emergence of new variants of the virus that partially or totally escape from the immune response elicited by the approved vaccines requires continuous monitoring of the emerging variants to update the content of the developed vaccines or modify them totally to match the new variants. Herein, we discuss the potential therapeutic and prophylactic interventions including repurposed drugs and the newly developed/approved vaccines, highlighting the impact of virus evolution on the immune evasion of the virus from currently licensed vaccines for COVID-19.
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Galal Yehya Abdelreheem Metwally, "In silico screening of potent inhibitors against COVID-19 key targets from a library of FDA-approved drugs", Springer- Nature, 2021
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Galal Yehya Abdelreheem Metwally, "Stress granules display bistable dynamics modulated by Cdk", Rockefeller University Press, 2021
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Department Related Publications
Eman Mahmoud Hassan Elmasry, "Studies on Chemoantibiotics Resistant patterns linked to Bacteriocin Production in Clinical Isolates of Gram -Negative Rods .", لايوجد, 1900
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Hassan Ahmed Abdelsalam Mohamed Badr, "Production of Aflatoxins by Immobilized Aspergillus flavus", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "The value of peritoneal lavage in peritonitis", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Effects of certain volatile oils on aflatoxins production by Aspergillus species locally isolated", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Effects of some quinolones in adhesiom , haemagglutination , outer membrane proteins and plasmid prophile of uropathogenic Escherichia coli ", لايوجد, 1900
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