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In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes
Faculty
Pharmacy
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Galal Yehya Abdelreheem Metwally
Staff Zu Site
Abstract In Staff Site
Journal:
Environmental Science and Pollution Research Springer- Nature
Volume:
Keywords :
, silico screening , potent bioactive compounds from
Abstract:
After the early advent of the Coronavirus Disease 2019 (COVID-19) pandemic, myriads of FDA-approved drugs have been massively repurposed for COVID-19 treatment based on molecular docking against selected protein targets that play fundamental roles in the replication cycle of the novel coronavirus. Honeybee products are well known of their nutritional values and medicinal effects. Bee products contain bioactive compounds in the form of a collection of phenolic acids, flavonoids, and terpenes of natural origin that display wide spectrum antiviral effects. We revealed by molecular docking the profound binding affinity of 14 selected phenolics and terpenes present in honey and propolis (bees glue) against the main protease (Mpro) and RNA-dependent RNA polymerase (RdRp) enzymes of the novel SARS-CoV-2 virus (the causative agent of COVID-19) using AutoDock Vina software. Of these compounds, p-coumaric acid, ellagic acid, kaempferol, and quercetin have the strongest interaction with the SARS-CoV-2 target enzymes, and it may be considered an effective COVID-19 inhibitor.
Author Related Publications
Galal Yehya Abdelreheem Metwally, "In-silico screening of naturally derived phytochemicals against SARS-CoV Main protease", Springer- Nature, 2021
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Galal Yehya Abdelreheem Metwally, "Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview", MDPI, 2021
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Galal Yehya Abdelreheem Metwally, "Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats", Springer- Nature, 2021
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Galal Yehya Abdelreheem Metwally, "Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics", MDPI, 2021
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Galal Yehya Abdelreheem Metwally, "In silico screening of potent inhibitors against COVID-19 key targets from a library of FDA-approved drugs", Springer- Nature, 2021
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Department Related Publications
Mona Abdelmoniem Elsayed Mahmmoud , "The value of peritoneal lavage in peritonitis", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Chemoantibiotic _ resistance in enteropathogenic Escherichia Coli Locally ", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Identification of different Candidia species according to its fatty acids contents.", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "The effects of various antimicrobial agents against Escherichia coli isolated from urine.", لايوجد, 1900
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