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Search Result For 'chemotherapy' , Result Number : 24

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Iman Ibrahim Attia Sweilem
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
chemotherapy
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Depressive symptoms and its influencing Factors among Elderly Cancer Patients Receiving Chemotherapy
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Nutritional Status and Its Contributing Factors among Older Adults with Cancer Receiving Chemotherapy
Asmaa Wageh Zaghlol Awad
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
rotein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin
Asmaa Ali Elsayed ally
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
effectiveness of progressive muscle relaxation technique on chemotherapy induced nausea and vomiting among breast cancer women:an intervention study
Amany Mohamed Ahmed Abdeldaiem
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Protecting Ovaries During Chemotherapy Through Gonad Suppression
Intesar Roshdy Mahdi
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
PREDICTIVE AND PROGNOSTIC VALUES OF HYPOXIA-INDUCIBLE FACTOR (HIF)-1Α AND TAU-PROTEIN EXPRESSION IN SEROUS OVARIAN CANCER (SOC) PATIENTS TREATED WITH CHEMOTHERAPY
Eman Amien Mahmoud Elgendy
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Gonadatrophin suppression to prevent chemotherapy-induced ovarian damage: a randomized controlled trial
Eman Hassan Abdelbary
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Expression of GSTP1, TOP2α and ALDH1A in triple negative breast cancer patients receiving neoadjuvant chemotherapy
Tayseer Refaat Ibrahim Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Clinicopathological and Prognostic Value of Immunohistochemical Expression of CD44 (Stem Cell Marker) and Ki67 in Serous Ovarian Cancer Taiseer R. Ibrahim, Samar M. Abdelraouf, Mohamed Abdelgawad, Amira Elwan Abstract Introduction: Failure of effective treatment of epithelial carcinoma of the ovary necessitates searching factors that lead to resistance to chemotherapy and recurrence. Cancer stem cell theory hypothesis provides an explanation of how small group of cells inside the tumour remain resistant to treatment. CD44 has been considered as cancer stem cell marker in multiple malignancies but its role in Ovarian Serous Carcinoma (OSC) is still controversial. Aim: To investigate the expression of stem cell marker CD44 and proliferative activity using Ki67 immunostaining in serous ovarian carcinoma and their relation to clinical and pathological variables and outcome of the patients. Materials and Methods: The present study was a prospective study done on 45 patients with serous ovarian tumours, the ovarian sections obtained from the patients were immunostained by CD44 and Ki67 immunohistochemical markers. The Overall Survival (OS), Disease Free Survival (DFS) and response to treatment were investigated and analysed. Results: Both CD44 and Ki67 were positive in patients with increased grade and advanced stage and the difference was highly statistically significant (p=0.001 and p<0.001, respectively). CD44 and Ki67 expression were higher in bilateral cancer with presence of lymph node and distant metastasis than in unilateral tumours without lymph node and distant metastasis. The present study found positive relation between CD44 and Ki67 expression (p=0.006). CD44 and Ki67 positive expression level in OSC had a significantly shorter 3-year DFS than the patient group with negative expression of CD44 and Ki67 (p=0.020 and p=0.002, respectively). Conclusion: This study demonstrated that CD44 and Ki67 expression were significantly associated with high grade and late stage serous ovarian carcinoma, and their high expression was associated with poor prognosis and resistance to chemotherapy, so proper quantification may play a vital promising function in choosing targeting therapy and predicting more better result outcome.
Tayseer Refaat Ibrahim Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Expression of Stem Cell Marker OCT4 and Epidermal Growth Factor Receptor Predict Recurrence in Transitional Cell Carcinoma of Bladder in Egyptian Patients Mona M. Ahmed ,Taiseer R. Ibrahim, Safa A.Balata, Mohamed Malek, Ibrahim Ismail, Ayman Omar Abstract Introduction: In the past, the prognosis of bladder cancer was dependent on the presence of muscle invasion. Recently High-Grade T1 (HGT1) Transitional Cell Carcinoma (TCC), found to be associated with similar behaviour and prognosis even following Bacillus Calmette Guerin (BCG) therapy. Recognition of new markers that may help in selection of high-risk cases that need aggressive treatment even in the early stage to avoid unwanted toxicity of chemotherapy has to be high priority. Aim: To evaluate the prognostic value of Octamer-Binding Transcription Factor 4 (OCT4) and Epidermal Growth Factor Receptor (EGFR) immunohistochemical expression in urothelial carcinoma of the bladder and their effect as well as the vascular invasion on the recurrence of these tumours. Materials and Methods: Prospective cohort study conducted in Zagazig University hospital from January 2010 till December 2013. Immunohistochemical staining of OCT4, EGFR and Cd34 for 68 cases of bladder cancer samples was done. The correlation between the expressions of each marker and clinic-pathologic parameters was then analyzed. Results: OCT4 was detected in 53 patients (77.9%) of total cases. EGFR showed high expression in 25 of cases. 18 and 25 cases revealed low and no EGFR expression, respectively. There was a significant association between intensity of OCT4 expression and tumour grade (p<0.001), muscle invasion (p<0.001), vascular invasion (p=0.004) and stage (p=0.001). Significant association was established between EGFR expression and tumor size, grade, lamina propria, muscle and vascular invasion and stage (p 0.005, <0.001, 0.001, <0.001, respectively). Significant association observed between OCT4, EGFR expression and vascular invasion and recurrence (p=0.026, 0.001 and 0.002 respectively). Conclusion: Using selective inhibitors for EGFR and OCT4 especially that approved for EGFR in treating selected cases of urothelial carcinoma of bladder could suppress tumor growth. These markers in addition to presence of vascular invasion have to be used in screening of high risk noninvasive group that benefits from target therapy
Sameh Mahmoud Abdelmoneim Mahmud
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Multi-detector computed tomography (MDCT) findings of chemotherapy induced hepatic changes
Samar Mahmoud Abdelhalim Mustafa
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Methylenetetrahydrofolate Reductase Gene Polymorphism In Pediatric Acute Lymphoblastic Leukemia : Risk And Chemotherapy Toxicity Ebtsam Ibrahim1, Samar M Sharaf1 , Mervat Atfy2 Department of Clinical Pathology1 and Pediatrics 2 The Egyptian Journal Of Haematology March (2011)
Shereen Attia Shazly
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Correlations between P53 mutations and response to Paclitaxel/Cisplatin Chemotherapy in Patients with Advanced Epithelial Ovarian Cancer
Annan Fathy Mohamed AbdelAal
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Prognostic impact of Apaf-1, Cyclin D1, and AQP-5 in serous ovarian carcinoma treated with the first-line chemotherapy
Alaaeldeen Ahmed Mohamed Faraj
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
CAN RESECTION OF LIVER METASTASIS IMPROVE SURVIVAL AFTER RESECTABILITY CONVERSION CHEMOTHERAPY IN PATIENTS WITH METASTATIC COLO-RECTAL CANCER?
Lubna Abdul -Aziz Abdul- Aziz Muhamed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Choosing the Appropriate Individualized Adjuvant Chemotherapy in Stage III Colon Cancer Patients Under and Over 70 Years
Lubna Abdul -Aziz Abdul- Aziz Muhamed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Prognostic significance of lymphocyte-to-monocyte ratio in patients with classical Hodgkin lymphoma before and after receiving first-line chemotherapy
Lubna Abdul -Aziz Abdul- Aziz Muhamed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
The validity of giving adjuvant capecitabine after standard anthracycline and/or taxanes based Neo-/Adjuvant Chemotherapy in Early Triple-Negative breast cancer patients: An Egyptian prospective multicentric phase III trial
Mona Said Mustafa Mohammed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
spredictive and SOC patients received first line chemotherapyprognostic role of HIF1 & TAU protein expresio
Mohamed Hassan Mohamed Abdel Azeem
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
chemotherapy
Manar Ahmed Ibrahim AbuZaid
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Characterization and dielectric properties of magnetic nanoparticles (Ferrofluid) conjugated with chemotherapy drug for medical application
Mona Salah Fathallah Attya
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Two Dimensional versus Three Dimensional Radiation Therapy After Conservative Surgery And Adjuvant Chemotherapy of Early Left Breast Cancer
Mona Fathi Ali
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
role of occupational health and safety programin improving knowlaedge and practice among nurses exposed to chemotherapy at zagazig universty hospitals