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Search Result For 'Carcinogenesis' , Result Number : 4

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Ahmed Ezat Mahmoud Mohamed El Zowalaty
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Carcinogenesis
Tayseer Refaat Ibrahim Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Clinicopathological significance and correlation of fatty acid synthase (FASN) and HER-2 expression in infiltrating duct carcinoma of the breast Samah Said Elbasateeny1, Taiseer Refat Ibrahim1, Ibtsam Shehta Harera2 ABSTRACT Objective: This study aimed to correlate the immunohistochemical expression of fatty acid synthase (FASN) and HER-2 with the clinicopathological variables in breast infiltrating duct carcinoma (IDC) to identify the impact of marker expression on tumor behavior and mammary carcinogenesis and to detect the correlations between the two markers. Methods: Immunohistochemical expressions of FASN and HER-2 were evaluated in 77 breast case including 10 normal breast, 12 ductal carcinoma in situ (DCIS) and 55 IDC and correlated with clinicopathological variables. The obtained data were statistically analyzed. Results: FASN was overexpressed in 91.7% and 70.9% of DCIS and IDC, respectively, with a significant difference from the normal (P = 0.000). In IDC, the expression of FASN was significantly more expressed in low-grade IDC (P = 0.031). FASN was significantly upregulated in larger tumors and lymph node metastasis (P = 0.017 and P = 0.046, respectively). The expression of FASN had a significant negative correlation with progesterone receptor (PR) (P = 0.05). HER-2 was overexpressed in 50% and 25.45% of DCIS and IDC, respectively, with a significant difference from the normal (P = 0.026). HER-2 was only expressed in high-grade DCIS (P = 0.007). In IDC, the expression of HER-2 was significantly up-regulated in larger tumors and lymph node metastasis (P = 0.033 and P = 0.015, respectively). The expression of HER-2 had a significant negative correlation with estrogen receptor (ER) and PR (P = 0.001 and P = 0.023, respectively). Correlation between the expression of FASN and HER-2 in IDC, revealed a significant positive correlation (Spearman correlation [r] = 0.374, P = 0.005). Conclusions: We concluded that overexpression of FASN and HER-2 may facilitate the early diagnosis of IDC. In IDC, their over expression might warn of a more aggressive course. Our correlation found that FAS expression is closely associated with over expression of HER-2 in IDC.
Tayseer Refaat Ibrahim Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer Samar M. Abdelraouf , Taiseer R. Ibrahim, Lobna A. Abdelaziz, Mohamed I. Farid, Salem Y. Mohamed Abstract Background :Colorectal carcinoma (CRC) is the third most common human cancer. Twist, a basic helix-loop-helix (bHLH) transcription factor, is an epithelial-mesenchymal transition ((EMT) inducer that has been involved in carcinogenesis and chemoresistance. Also, the enhancer of Zeste homolologue2 (EZH2), a member of the polycomb group of genes, had been associated with poor prognosis in several malignancies. Objective :To evaluate the expression of Twist1 and EZH2 in colon carcinoma in Egyptian patients and its relation to clinico-pathological parameters, prognosis, and survival. Methods: Twist1 and EZH2 expressions were evaluated immunohistochemically in 50 cases of colorectal tumors (12 colon adenomas and 38 colon carcinomas) and 20 samples from normal colonic mucosa. Results :The expression of Twist1 and EZH2 was significantly higher in colon adenoma and carcinoma than that in normal colonic mucosa (P< 0.05). Twist1 and EZH2 expressions were associated with decreased tumor differentiation, advanced stage, and lymph node metastasis. Twist1 and EZH2 expressions were significantly related to 3-year disease-free survival (P=0.005 and 0.002 respectively) and 3-year overall survival (P= 0.045 and 0.039, respectively). Conclusions:Twist1 and EZH2 may serve as prognostic predictors for colon carcinoma and may have a potential role as therapeutic targets in patients with colon carcinoma in the future.
Hoda Abdel Hamid Ahmed Alhjursy
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
carcinogenesis