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Chitosan, derivatives, and its nanoparticles: Preparation, physicochemical properties, biological activities, and biomedical applications – A comprehensive review
Faculty
Agriculture
Year:
2025
Type of Publication:
ZU Hosted
Pages:
Authors:
Ahmed Mohamed Saad Mousttafa
Staff Zu Site
Abstract In Staff Site
Journal:
International Journal of Biological Macromolecules Elsevier
Volume:
Keywords :
Chitosan, derivatives, , , nanoparticles: Preparation, physicochemical properties,
Abstract:
Chitosan, derived from the deacetylation of chitin, is the second most widely used natural polymer, valued for its nontoxic, biocompatible, and biodegradable properties. These attributes have driven extensive research into diverse applications of chitosan and various derivatives. The key characteristics of chitosan muco-adhesion, permeability enhancement, drug release modulation, and antimicrobial activity are primarily due to its amino and hydroxyl groups. However, the limited solubility of raw chitosan in water and most organic solvents has posed challenges for broader application. Numerous chemically modified derivatives have been developed to address these inadequacies with improved physical and chemical properties. Among these derivatives, chitosan nanoparticles have emerged as versatile drug carriers with precise release kinetics and the capacity for targeted delivery, greatly enhancing drug efficacy and safety profiles for therapeutic applications. Due to these unique physicochemical properties, chitosan and chitosan nanoparticles are promising for improved drug delivery, vaccine administration, transplantation, gene therapy, and diagnostics. This review examines the physicochemical properties and bioactivities of chitosan and chitosan nanoparticles, emphasizing their broad-ranging biomedical applications.
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Ahmed Mohamed Saad Mousttafa, "Polyphenolic extracts from pomegranate and watermelon wastes as substrate to fabricate sustainable Silver nanoparticles with larvicidal effect against Spodoptera littoralis", دولي, 2021
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Ahmed Mohamed Saad Mousttafa, "Phytogenic compounds from avocado (Persea americana L.) extracts; antioxidant activity, amylase inhibitory activity, therapeutic potential of type 2 diabetes", elsevier, 2021
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Department Related Publications
Mohamed TalaatAbdou Mohamed El-Sadony, "improvement of growth and yield of pea plants using integrated fertilization management", universal gournal of agriculturel research, 2015
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Ahmed Abdelmohsen Mahdi , "Influence of enzymatic hydrolysis on the biochemical methane potential of Chlorella vulgaris and Scenedesmus sp.", wily, 2016
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Behery Ahmid Ali Salman, "Efficiency of two molecular tools based on DNA used for differentiating some microbial strains", AUJAS, Ain Shams Univ, 2019
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Behery Ahmid Ali Salman, "SENSORY EVALUATION, ANTIOXIDANT, ANTIMICROBIAL ACTIVITIES AND COLOUR OF STRAWBERRY NECTAR ENRICHED WITH PRODIGIOSIN PIGMENT PRODUCED FROM SERRATIA MARCESCENS", Pak. J. Biotechnol, 2019
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Mohamed TalaatAbdou Mohamed El-Sadony, "Effects of dietary biological or chemical-synthesized nano-selenium supplementation on growing rabbits exposed to thermal stress", MDPI, 2020
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