The cigarette beetle, Lasioderma serricorne Fabricius (Coleoptera: Anobiidae), is an important pest of stored products in the world which caused major economic losses that required many strategies for controlling insect pest. This study investigated native entomopathogenic nematodes (EPNs) and imported EPN species alone at different IJs concentrations or in combination with three application rates (recommended, quarter and half recommended concentrations) of lambda-cyhalothrin, emamectin benzoate and indoxacarb against the third and the fourth larval instars of its pest under laboratory conditions.The results showed that The native H.bacteriophora (Ar-4 strain) and the imported H.bacteriophora (HP88 strain) were more effective against the fourth larval instar of L. serricorne than the third instar followed by S.carpocapsae (All strain) while H.bacteriophora (Ba-1 strain) and S. feltiae strain were the least efficacy. According to LT50 of tested EPNs, 100 IJs/larva was the best concentration used against the larvae instars of L. serricorne. As well as, the fourth instar was more susceptible to the tested applications of pesticides than the third larval instar. Moreover, The application with a quarter recommended dose of indoxacarb was the most toxicity application against the fourth instar when compared to lambda-cyhalothrin and emamectin benzoate. On the other hand, the effects of the interactions between native and imported EPNs varied greatly as stated by application rates of tested insecticides and juveniles' concentration of EPNs. It is concluded that the best interaction effect was obtained with quarter recommended application (0.25 RC) of lambda-cyhalothrin when combined with EPNs at 100 IJs/larva, which displayed synergistic effect to overcome incompatibility particularly with heterorhabditid species, the effect that could be beneficial when making progress the integrated program for stored-product pests.