ancer significantly affects patients' quality of life (QoL), impacting their physical, emotional, and social well-being. Recently, smartphone-based e health interventions have been investigated as a method to improve QoL for cancer patients by providing customized support. This study assesses the effectiveness of these interventions. Using a quasi-experimental design, the research involved pre- and post-intervention tests. A total of 106 cancer patients were recruited through convenience sampling. A structured questionnaire was used, covering socio-demographic characteristics, medical history, cancer knowledge, and a QoL scale. Data were collected initially and two months after the intervention, which included lectures, group discussions, and scenario-based activities. Results indicated significant improvements in patients’ knowledge and QoL scores post-intervention. There were also notable differences in knowledge scores related to socio demographic factors before and after the intervention. The findings suggest that smartphone-based e-health interventions effectively enhance cancer patients' knowledge and QoL. Successful implementation of these interventions can lead to better health outcomes. Continuous training for nurses and other healthcare providers is essential to maximize the benefits of e-health. This study highlights the potential of smartphone technology to support continuous care for cancer patients, potentially reducing hospital readmissions and improving self-care and health literacy.