Background: The direct impact of the pandemic refers to human life and the functioning of the healthcare system, hospitals, and outpatient clinics. The Patients' Rights introduces the term of fundamental rights of patients. Aim: To explore staff nurse's compliance with patient's rights during Covid 19 Pandemic as an indicator of educational intervention program effectiveness. Subjects and Methods: A quasi-experimental research design was utilized, including staff nurses (239) who were worked in the surgical hospital of Zagazig University Hospitals. A self-administered questionnaire including three scales to assess studied subjects' knowledge, awareness and practice toward patient's rights during Covid 19 Pandemic pre/post and follow-up assessment. Results: total mean knowledge score, before the program total mean score of staff nurses knowledge was 37.60±2.7 which increased to 75.67±1.92 at the post program phase, and declined to 69.42±3.72at the followup phase. These improvements were statistically significant. Were a statistically highly significant. Regarding total mean awareness score, before the program total mean score of staff nurses awareness was14.60±2.7which increased to 29.67±1.92 at the post program phase, and at the follow-up phase and only 8.8 % of staff nurses had good practices of patient’s right. This increased to (50.6%) at the post program phase. Conclusions: The program had a significant compliance with patient's rights during Covid pandemic and had a large effect on total knowledge, awareness and practice of staff nurses post-intervention. Recommendations: Regular in-service refresher courses should be conducted for nurses to fill deficiencies of their knowledge and practice regarding patient's rights during pandemic and crises, with continuous assessment of their knowledge and practice.