A new natural compound, named 6-O-(3’’,4’’-dimethoxycinnamoyl) catalpol, was isolated from the defatted alcoholic extract of the fl owering parts of Buddleja asiatica Lour. (family Scrophulariaceae). Other separated known compounds included steroids (β-sitosterol, stigmasterol, stigmasterol-O-glucoside, β-sitosterol-O-glucoside), iridoid glucosides (methyl catalpol, catalpol, aucubin), phenylpropanoids (isoacteoside and acteoside), a triterpene saponin (mimengoside A), fl avonoids (diosmin and linarin) in addition to the free sugars mannitol and sucrose. The structures of the isolated compounds were established by 1 H and 13C NMR and mass spectrometry. Furthermore, the polar fraction of the fl owering parts and the roots showed substantial antihepatotoxic activity comparable to that of the lignan silymarin