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Echinops taeckholmiana Amin: Optimization of a Tissue Culture Protocol, Biological Evaluation, and Chemical Profiling Using GC and LC-MS
Faculty
Pharmacy
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Rasha Adel Abdelmoneim Attia
Staff Zu Site
Abstract In Staff Site
Journal:
ِACS Omega American chemical society
Volume:
Keywords :
Echinops taeckholmiana Amin: Optimization , , Tissue Culture
Abstract:
There have been no reports published on the rare Echinops taeckholmiana growing wildly in Egypt. So, this study aimed to preserve it through method optimization of in vitro seed germination, besides callus formation from induced seedlings. Chemical profiling using gas chromatography-mass spectrometry (GC-MS) analysis of the n-hexane fraction afforded 29 identified components, mainly fatty acids esters, sesquiterpenes, triterpenes, one thiophene, and bis(2-ethylhexyl) phthalate. Ultra-performance liquid chromatography-electron spray ionization/tandem mass spectrometry (UPLC-ESI/MS-MS) analysis of total alcoholic root and induced calli extracts resulted in 68 metabolites. Taraxeryl acetate, β-sitosterol, stigmasterol-3β-D-glucoside, and 1,1,1-kestopentaose were identified from the defatted root extract, which inhibited α-amylase (IC50 54.6 μg/mL) and α-glucosidase (60.4 μg/mL) enzymes compared with acarbose (IC50 values of 30.57 and 34.71 μg/mL, respectively). Moreover, it showed moderate activity against HepG2 (IC50 31.1 ± 1.4 μg/mL) and no activity against M-NFS-60 cell lines compared to cisplatin (IC50 3.25 ± 1.4 and 8.37 ± 0.25, respectively).
Author Related Publications
Rasha Adel Abdelmoneim Attia , "Chemical composition and biological activities of the essential oil of Tanacetum sinaicum Del. grown in Egypt", AkiNik Publications, 2019
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Rasha Adel Abdelmoneim Attia , "The delayed death-causing nature of Rosmarinus officinalis leaf extracts and their mixture within experimental chronic toxoplasmosis: Therapeutic and prophylactic implications", ELSEVIER, 2021
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Rasha Adel Abdelmoneim Attia , "Metabolic Profiling and Biological Activities of The Aerial Parts of Micromeria imbricata Forssk. Growing in Saudi Arabia", ELSEVIER, 2021
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Rasha Adel Abdelmoneim Attia , "Phytoconstituents Profile and UPLC-ESI-MS/MS Analysis of Centaurea pumilio L. Callus Culture Following Elicitation", Asian Network for Scientific Information, 2021
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Rasha Adel Abdelmoneim Attia , "Variation in the volatile constituents of wild and in vitro propagated Tanacetum sinaicum Del. ex DC through GC-MS chemical fingerprint", CSIR-NISCAIR, 2021
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Department Related Publications
Ehsan Mahmoud Abdelaziz Abozied, "The production and Biosynthesis of Medical Agents in Tissue Culture a Study", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "8) Macro-and Micromorphology of the Leaf, Stem & Root of Amaranthus Chlorostachys Willed, Growing in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "Macro- and Micromorphology of the Leaf, Stem & Root of Gomphocarpus Sinaicus Boiss. Family Asclepiadaceae. Growing in Egypt", لايوجد, 1900
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Samyah Salah Mohamed Hafez, "The Pharmacognostical study of Launaea Nudicaulis ( L. ) Hook Family", لايوجد, 1900
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Samyah Salah Mohamed Hafez, " Phytochemical and Biological Studies of Lotus corniculatus var.", لايوجد, 1900
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