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BM-MSCs alleviate diabetic nephropathy in male rats by regulating ER stress, oxidative stress, inflammation, and apoptotic pathways
Faculty
Veterinary Medicine
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Tariq Khamis Kamal Ahmed Khamis
Staff Zu Site
Abstract In Staff Site
Journal:
Frontiers in Pharmacology mdpi
Volume:
Keywords :
BM-MSCs alleviate diabetic nephropathy , male rats
Abstract:
Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a promising option to mitigate several diabetic complications. Methods: In this study, we evaluated the therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) in a rat model of STZ-induced DN. After the confirmation of diabetes, rats were treated with BM-MSCs and sacrificed at week 12 after treatment. Results: Our results showed that STZ-induced DN rats had extensive histopathological changes, significant upregulation in mRNA expression of renal apoptotic markers, ER stress markers, inflammatory markers, fibronectin, and intermediate filament proteins, and reduction of positive immunostaining of PCNA and elevated P53 in kidney tissue compared to the control group. BM-MSC therapy significantly improved renal histopathological changes, reduced renal apoptosis, ER stress, inflammation, and intermediate filament proteins, as well as increased positive immunostaining of PCNA and reduced P53 in renal tissue compared to the STZ-induced DN group. Conclusion: In conclusion, our study indicates that BM-MSCs may have therapeutic potential for the treatment of DN and provide important insights into their potential use as a novel therapeutic approach for DN.
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Tariq Khamis Kamal Ahmed Khamis, "Curative and protective potentials of decoction of Moringa oleifera leaf on the streptozotocin-Induced Diabetes mellitus in albino Rats", Iraqi Journal of Veterinary Sciences, 2022
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Tariq Khamis Kamal Ahmed Khamis, "β-Cell Autophagy Pathway and Endoplasmic Reticulum Stress Regulating-Role of Liposomal Curcumin in Experimental Diabetes Mellitus: A Molecular and Morphometric Study", MDPI, 2022
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Tariq Khamis Kamal Ahmed Khamis, "Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1–PPAR-α–Kisspeptin–Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model", elsevier, 2021
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Tariq Khamis Kamal Ahmed Khamis, "Clinical implication and prognostic significance of FLT3-ITD and ASXL1 mutations in Egyptian AML patients: A single-center study", IOS press, 2021
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Tariq Khamis Kamal Ahmed Khamis, "Anti-inflammatory, Analgesic and Ulcerogenic Potency of Curcumin in Comparison with Celecoxib and Prednisolone", Assiut University, 2021
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Department Related Publications
Ahmed Abdoh Said Muhmmd, "Pharmacological Effects of Fish and Soyabean oils in Sheep", لايوجد, 1900
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Ahmed Abdoh Said Muhmmd, "العلاقة بين تاثيرصمغ النحل كواقى للمعدة وقدرتة كمضاد للاكسدة ", لايوجد, 1900
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Alsayed Ahmed Abdelazeez , "Efficacy and pharmacokinetic pattern of norfloxacin in both healthy and diseased chickens. proceeding from the 1st Conf. on The role of Scientific Research and Technological Development in the Protection of Environment Against Pollution ", لايوجد, 1900
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Alsayed Ahmed Abdelazeez , "A prelude to the clinical use of fertagyl and prosolvin in male infertility ", لايوجد, 1900
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