Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis

Faculty Veterinary Medicine Year: 2023
Type of Publication: ZU Hosted Pages: 19
Authors:
Mahmoud Ibrahim Mohieeldeen
Journal: Molecules Nagoya City University Volume:
Keywords : Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma    
Abstract:
In the present study, novel chalcone derivatives were synthesized and evaluated for their antitumor activity against cancer cells of two origins (mouse and human) breast carcinoma. Results showed that chalcone with a methoxy group exhibited enhanced cytotoxicity, cell cycle arrest, and proapoptotic activity, leading to reduced cell growth. Their inhibitory effect on anti-apoptotic proteins, particularly cIAP1, BCL2, and EGFRK proteins was also confirmed by molecular docking.
    
     
 
       

Author Related Publications

  • Mahmoud Ibrahim Mohieeldeen, "synthesis, characterization and stability evaluation of novel hybrid nanoparticles and their biomedical and chemical applications", journal of oleo science, 2017 More
  • Mahmoud Ibrahim Mohieeldeen, "Potential Effects of Anthocyanin-Rich Roselle (Hibiscus sabdariffa L.) Extract on the Growth, Intestinal Histomorphology, Blood Biochemical Parameters, and the Immune Status of Broiler Chickens", MDPI, 2022 More
  • Mahmoud Ibrahim Mohieeldeen, "Pseudomonas putida infection induces immune‑antioxidant, hepato‑renal, ethological, and histopathological/immunohistochemical disruptions in Oreochromis niloticus: the palliative role of titanium dioxide nanogel", BMC a part of Springer, 2024 More
  • Mahmoud Ibrahim Mohieeldeen, "Effect of fish meal substitution with dried bovine hemoglobin on the growth, blood hematology, antioxidant activity and related genes expression, and tissue histoarchitecture of Nile tilapia (Oreochromis niloticus)", Elseiver, 2022 More
  • Mahmoud Ibrahim Mohieeldeen, "Physiological, biochemical, apoptosis-linked gene expression, and histopathological insights in Nile catfish subjected to toxicity by magnetite nano gel", Springer nature, 2025 More

Department Related Publications

  • Amany Ibrahim Ahmed alsayed, "The effects of chitosan-vitamin C nanocomposite supplementation on the growth performance, antioxidant status, immune response, and disease resistance of Nile tilapia (Oreochromis niloticus) fingerlings", elsevier, 2020 More
  • Amany Ibrahim Ahmed alsayed, "Synthetic Salicylates and/ or Pioglitazone Ameliorative Effect in Type 2 Induced Diabetic Rats", Nexus academic publishers, 2019 More
  • Amany Ibrahim Ahmed alsayed, "Antidiabetic Effect of Pumpkin Seeds and Gum Arabic and/or Vildagliptin on type 2 Induced Diabetes in Male Rats", unique scientific publisher, 2020 More
  • Amany Ibrahim Ahmed alsayed, "The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity", academicjournals.org, 2028 More
  • Doaa Mohamed Abdelfatah Ali Elsayed, "Effect of Dietary Medium-Chain α-Monoglycerides on the Growth Performance, Intestinal Histomorphology, Amino Acid Digestibility, and Broiler Chickens’ Blood Biochemical Parameters", MDPI, 2020 More
Tweet