Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis

Faculty Veterinary Medicine Year: 2023
Type of Publication: ZU Hosted Pages: 19
Authors:
Mahmoud Ibrahim Mohieeldeen
Journal: Molecules Nagoya City University Volume:
Keywords : Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma    
Abstract:
In the present study, novel chalcone derivatives were synthesized and evaluated for their antitumor activity against cancer cells of two origins (mouse and human) breast carcinoma. Results showed that chalcone with a methoxy group exhibited enhanced cytotoxicity, cell cycle arrest, and proapoptotic activity, leading to reduced cell growth. Their inhibitory effect on anti-apoptotic proteins, particularly cIAP1, BCL2, and EGFRK proteins was also confirmed by molecular docking.
    
     
 
       

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