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Antidiabetic Effect of Pumpkin Seeds and Gum Arabic and/or Vildagliptin on type 2 Induced Diabetes in Male Rats
Faculty
Veterinary Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Amany Ibrahim Ahmed alsayed
Staff Zu Site
Abstract In Staff Site
Journal:
International Journal of Veterinary Science unique scientific publisher
Volume:
Keywords :
Antidiabetic Effect , Pumpkin Seeds , , Arabic and/or
Abstract:
Metabolic syndrome is the accompaniment of multiple risk factors for atherosclerotic cardiovascular disease and type 2 diabetes (T2D) including glucose intolerance, hypertension and dyslipidemia where obesity is the basic element at this syndrome. T2DM is a heterogeneous metabolic syndrome resulting from genomic-environment complex interaction. Pumpkin seeds and gum Arabic are two natural products with an obvious hypoglycemic role. Vildagliptin is a selective inhibitor of dipeptidylpeptidase-4 (DPP-IV), and a certified therapy for T2DM. This study has been destined to assess in vivo the hypoglycemic impact of pumpkin seeds and gum Arabic in compare with vildagliptin and their combination treatments. 70 male albino rats were randomly separated into seven groups of ten each: control non-diabetic, control non-treated diabetic, diabetic treated with pumpkin seed extract (300mg/kg/day), diabetic treated with gum Arabic (500mg/kg/day), diabetic treated with vildagliptin (10mg/kg/day), diabetic treated with a combination of pumpkin seed extract and vildagliptin, and diabetic treated with a combination of gum Arabic and vildagliptin.T2DM was stimulated by feeding rats on high fat-high fructose/sucrose diet regimen (HFHF/S) for 12 weeks. Biochemical assessment has revealed that pumpkin seed extract, gum Arabic and vildagliptin can alleviate the severity of hyperglycemia, insulin resistance, dyslipidemia and depress glucagon secretion
Author Related Publications
Amany Ibrahim Ahmed alsayed, "The effects of chitosan-vitamin C nanocomposite supplementation on the growth performance, antioxidant status, immune response, and disease resistance of Nile tilapia (Oreochromis niloticus) fingerlings", elsevier, 2020
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Amany Ibrahim Ahmed alsayed, "Synthetic Salicylates and/ or Pioglitazone Ameliorative Effect in Type 2 Induced Diabetic Rats", Nexus academic publishers, 2019
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Amany Ibrahim Ahmed alsayed, "The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity", academicjournals.org, 2028
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Amany Ibrahim Ahmed alsayed, "Palliative role of colloidal silver nanoparticles synthetized by moringa against Saprolegnia spp. infection in Nile Tilapia: Biochemical, immuno-antioxidant response, gene expression, and histopathological investigation", Elseiver, 2022
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Amany Ibrahim Ahmed alsayed, "Moringa oleifera ethanolic extract attenuates tilmicosin-induced renal damage in male rats via suppression of oxidative stress, inflammatory injury, and intermediate filament proteins mRNA expression", Elsevier, 2021
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Department Related Publications
Hussein Ibrahim Hussin Elbelbesy , "The impact of staphylococcal mastitis on the level of milk IL-6 lysozyme and nitric oxide. ", لايوجد, 1900
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Hussein Ibrahim Hussin Elbelbesy , "Determination of serum progesterone , estrodiol 17-B , cortisol and prolactin during pregnancy in four breeds of rabbits", لايوجد, 1900
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Hussein Ibrahim Hussin Elbelbesy , "Immunoelectron microscopic studies on spore coat protein of bacillus megaterium.", لايوجد, 1900
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Hamad Amien Mohamed Elsadawy, "Effect of subanaesthetic mixture of halothane and nitrous oxide on the levels of glucose, cortisol and glucagone in the blood of female pregnant rats", لايوجد, 1900
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Sayedat Saad Abdelmegeed , "Serum biochemical alterations in rats as affected by copper administration.", لايوجد, 1900
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