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Future scope of plant-derived bioactive compounds in the management of methicillin-resistant Staphylococcus aureus: In vitro antimicrobial and antivirulence prospects to combat MRSA
Faculty
Veterinary Medicine
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Marwa Ibrahim Ibrahiem Abdelhamied
Staff Zu Site
Abstract In Staff Site
Journal:
Microbial Pathogenesis elsevier
Volume:
Keywords :
Future scope , plant-derived bioactive compounds , , management
Abstract:
Methicillin-resistant Staphylococcus aureus (MRSA) is a foremost human and animal pathogen with public health and veterinary significance causing hospital and community infections and contagious bovine mastitis. Due to its ability to develop multidrug resistance (MDR) and its pathogenicity, MRSA infection control is becoming a global concern. Natural antibacterial options are needed to combat MDR development and infectious dissemination. This study investigated the antimicrobial resistance and virulence genes profiling of MRSA isolates and explored the antivirulence efficacy of trans-cinnamaldehyde, thymol, and carvacrol essential oils (EOs) against multivirulent and MDR-MRSA isolates. Thirty six S. aureus isolates (25%) were retrieved, of which 34 (94.4%) were MRSA. A high prevalence of MDR (66.7%) was monitored and all 53 molecularly verified isolates possessed icaA and cna virulence genes. Moreover, 94.1% of these isolates were multivirulent with 23.5% of them carrying icaA, cna, eta, tst, and sea virulence genes. Our data proved superior in vitro antimicrobial and antivirulence activities of trans-cinnamaldehyde, thymol, and carvacrol. They inhibited the growth of multi-virulent and MDR-MRSA isolates and downregulated the transcription of examined virulence genes. Our study suggests using EOs as prospective antimicrobials with excellent antivirulence activities against MRSA isolates. We provided data regarding the eventual role of phytogenics in prevention and control of MRSA infection.
Author Related Publications
Marwa Ibrahim Ibrahiem Abdelhamied, "Impact of Nigella sativa and Clove Oils on Cell Wall Genes Expression in Multidrug Resistant Staphylococcus aureus", Zagazig, Egypt, 2016
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Marwa Ibrahim Ibrahiem Abdelhamied, "Molecular Detection of Fluoroquinolone Resistance among Multidrug-, Extensively Drug-, and Pan-Drug-Resistant Campylobacter Species in Egypt", MDPI, 2022
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Marwa Ibrahim Ibrahiem Abdelhamied, "Thymol nanoemulsion promoted broiler chicken’s growth, gastrointestinal barrier and bacterial community and conferred protection against Salmonella Typhimurium", springer nature, 2021
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Marwa Ibrahim Ibrahiem Abdelhamied, "Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using a Clostridium perfringens Challenge Model", MDPI, 2021
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Marwa Ibrahim Ibrahiem Abdelhamied, "Interactive effects of dietary quercetin nanoparticles on growth, flesh antioxidant capacity and transcription of cytokines and Aeromonas hydrophila quorum sensing orchestrating genes in Nile tilapia (Oreochromis niloticus)", ELSEVIER, 2021
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Department Related Publications
Wafaa Abdelhamed Alwan Eleraky, "Effect of replacement of cassava roots in the finishing broiler ration on growth performance and carcass yield. ", لايوجد, 1900
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Walaa Mahmoud Mohamed Abdelrazik , "دراسة تاثير العامل المضاد للثيروكسين على معدلات النمو وهرمونات التراى ايودوثيرونين والثيروكسين وهرمون النمو فى بدارى التسمين", لايوجد, 1900
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Walaa Mahmoud Mohamed Abdelrazik , "دراسة تاثير الكثافات المختلفة ومعدلات البروتين وعدد مرات التغذية على صحة ونمو اسماك البلطى الاوريا", لايوجد, 1900
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Mahmoud Fathy Ahmed Elgamal, "Some Studies on The Influence of Probiotic Supplementation on Growth Performance and Some Blood Parameters in Broiler Chickens.", كلية الطب البيطري, 2004
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Walaa Mahmoud Mohamed Abdelrazik , "Some Studies on The Influence of Probiotic Supplementation on Growth Performance and Some Blood Parameters in Broiler Chickens.", كلية الطب البيطري, 2004
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