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The ameliorative role of magnetite nano gel against lead toxicity in Clarias gariepinus: growth, oxidant/antioxidant stress, gene expression, and histopathological alterations of gills
Faculty
Veterinary Medicine
Year:
2024
Type of Publication:
ZU Hosted
Pages:
Authors:
Afaf Noureldeen Mohamed
Staff Zu Site
Abstract In Staff Site
Journal:
Aquaculture International Springer
Volume:
Keywords :
, ameliorative role , magnetite nano , against lead toxicity
Abstract:
Nowadays, nanomaterials are strongly introduced in the aquaculture sector as antidotal agents. Therefore, the current study aims to test magnetite ( Fe3O4) nano gel (MG) in relieving toxicity induced by lead (Pb) ions via assessment of stress condition, growth rate, oxidant/ antioxidant activity in serum, and histopathological lesions in gill tissue, plus different gene expressions in African catfish (Clarias gariepinus). Fish (n = 160) were haphazardly allotted into four groups (40/group; 10 fish per replicate) for 45 days. The first (control) and second (MG) groups were treated with 0 and 1.2 mg/L MG. The third (lead) and fourth (lead + MG) groups were treated with 0 and 1.2 mg/L MG, respectively, with exposure to lead chloride (69.30 mg/L). Findings showed that the exposure to lead resulted in a substantial increase in stress biomarkers (glucose and cortisol), plus the oxidant indicator (malondialdehyde) and a clear decline in the antioxidant parameters (superoxide dismutase and glutathione peroxidase) and growth indices (final body weight, weight gain, and specific growth rate). Additionally, there were prominent histopathological lesions in gill tissues including detached gill filaments and inflammatory cell infiltrates. The expression of inflammatory genes [transforming growth factor beta1 (TGF-β1), nuclear factor kappa beta 2 (NF-κβ2), interleukins (IL-1β and IL-8), and tumor necrosis factor-alpha (TNF-α)] showed a marked up-regulation with a down-regulation of the antioxidant gene [superoxide dismutase (SOD1)]. Surprisingly, the aqueous addition of MG in the lead-exposed group dismissed the serum biochemical changes with enhancement in the gills’ histological architecture, growth rate, and the expression of genes. Based on these results, MG (1.2 mg/L) is an innovative application as a safe antidotal agent against lead toxicity to sustain C. gariepinus’ health in the aquatic system and ensure the consumers’ safety.
Author Related Publications
Afaf Noureldeen Mohamed, "Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed", Elseviere, 2022
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Afaf Noureldeen Mohamed, "Palliative role of colloidal silver nanoparticles synthetized by moringa against Saprolegnia spp. infection in Nile Tilapia: Biochemical, immuno-antioxidant response, gene expression, and histopathological investigation", Elseiver, 2022
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Afaf Noureldeen Mohamed, "Alleviative effects of dietary Indian lotus leaves on heavy metals-induced hepato-renal toxicity, oxidative stress, and histopathological alterations in Nile tilapia, Oreochromis niloticus (L.)", Elsevier B.V., 2019
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Afaf Noureldeen Mohamed, "Protection of Nile tilapia, Oreochromis niloticus from aflatoxin B1 toxicity by dietary supplementation with Fennel essential oil and Saccharomyces cerevisiae", Elsevier B.V, 2017
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Afaf Noureldeen Mohamed, "The effects of the dietary supplementation of Echinacea purpurea extract and/or vitamin C on the intestinal histomorphology, phagocytic activity, and gene expression of the Nile tilapia", Elsevier Ltd, 2018
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