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LCMS/MS Phytochemical Profiling, Molecular, Pathological, and Immune-Histochemical Studies on the Anticancer Properties of Annona muricata
Faculty
Pharmacy
Year:
2023
Type of Publication:
ZU Hosted
Pages:
1-18
Authors:
Rehab Hamed Abdallah Mohamed
Staff Zu Site
Abstract In Staff Site
Journal:
molecules mpdi
Volume:
28
Keywords :
LCMS/MS Phytochemical Profiling, Molecular, Pathological, and Immune-Histochemical
Abstract:
Annona muricate is a tropical plant that is well-known for its edible fruit of therapeutic interest. LCMS/MS analyses were applied to identify phytoconstituents of the ethanolic extract of the whole fruits and the aqueous extract of the edible fruit part, in addition to the investigation of their anticancer properties against Ehrlich ascites carcinoma (EAC) in male albino mice. LCMS/MS analyses resulted in the identification of 388 components, representing a wide array of classes of compounds, including acetogenins as the major constituents, alkaloids, flavonoids, and phenolics. Among them, four compounds were tentatively characterized as new compounds (1–4), including an acid derivative, protocatechuic-coumaroyl-quinic acid (1), and three flavonoid derivatives, dihydromyricetin galloyl hexoside (2), apigenin gallate (3), and dihydromyricetin hexouronic acid hexoside (4). Induction with EAC cells resulted in abnormalities in the gene expression of proapoptotic genes (Bax and caspase-3) and anti-apoptotic gene (Bcl-2) in the tumor mass. Moreover, microscopic, histopathological, and immune-histochemical examinations of the tumor mass and liver tissues exhibited extensive growth of malignant Ehrlich carcinoma cells and marked hydropic degeneration of hepatocytes and infiltration by tumor cells to liver tissue with marked inflammatory reaction. These abnormalities were markedly ameliorated aftertreatment of EAC mice with A. muricata extracts.
Author Related Publications
Rehab Hamed Abdallah Mohamed, "Effect of Roasting, Boiling, and Frying Processing on 29 Polyphenolics and Antioxidant Activity in Seeds and Shells of Sweet Chestnut (Castanea sativa Mill.)", MDPI, Basel, Switzerland, 2021
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Rehab Hamed Abdallah Mohamed, "New pentacyclic triterpene ester and flavone glycoside from the biologically active extract of Carduus pycnocephalus L", Journal of pharmacognosy and phytotherapy, 2015
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Rehab Hamed Abdallah Mohamed, "Phytochemical and biological study of Albizia lebbeck stem bark", J. Chem. Pharm. Res, 2015
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Rehab Hamed Abdallah Mohamed, "NEW SAPONINS FROM ALBIZIA LEBBECK (L) BENTH FLOWERS", International Journal of Pharmaceutical Sciences and Research, 2016
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Rehab Hamed Abdallah Mohamed, "Macro- and Micromorphological Study of Albizia lebbeck (L.) Benth Cultivated in Egypt", Zagazig J. Pharm. Sci, 2015
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Department Related Publications
Ehsan Mahmoud Abdelaziz Abozied, "The production and Biosynthesis of Medical Agents in Tissue Culture a Study", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "8) Macro-and Micromorphology of the Leaf, Stem & Root of Amaranthus Chlorostachys Willed, Growing in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "Macro- and Micromorphology of the Leaf, Stem & Root of Gomphocarpus Sinaicus Boiss. Family Asclepiadaceae. Growing in Egypt", لايوجد, 1900
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Samyah Salah Mohamed Hafez, "The Pharmacognostical study of Launaea Nudicaulis ( L. ) Hook Family", لايوجد, 1900
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Samyah Salah Mohamed Hafez, " Phytochemical and Biological Studies of Lotus corniculatus var.", لايوجد, 1900
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