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Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
Faculty
Veterinary Medicine
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Amany Abdalaziz
Staff Zu Site
Abstract In Staff Site
Journal:
Antioxidants MDPI
Volume:
Keywords :
Liposome-Encapsulated Berberine Alleviates Liver Injury in Type
Abstract:
In the advanced stages of type 2 diabetes mellitus (T2DM), diabetic liver damage is a common complication that can devastate a patient’s quality of life. The present study investigated the ability of liposomal berberine (Lip-BBR) to aid in ameliorating hepatic damage and steatosis, insulin homeostasis, and regulating lipid metabolism in type 2 diabetes (T2DM) and the possible pathways by which it does so. Liver tissue microarchitectures and immunohistochemical staining were applied during the study. The rats were divided into a control non-diabetic group and four diabetic groups, which are the T2DM, T2DM-Lip-BBR (10 mg/kg b.wt), T2DM-Vildagliptin (Vild) (10 mg/kg b.wt), and T2DM-BBR-Vild (10 mg/kg b.wt + Vild (5 mg/kg b.wt) groups. The findings demonstrated that Lip-BBR treatment could restore liver tissue microarchitectures, reduce steatosis and liver function, and regulate lipid metabolism. Moreover, Lip-BBR treatment promoted autophagy via the activation of LC3-II and Bclin-1 proteins and activated the AMPK/mTOR pathway in the liver tissue of T2DM rats. Lip-BBR also activated the GLP-1 expression, which stimulated insulin biosynthesis. It decreased the endoplasmic reticulum stress by limiting the CHOP, JNK expression, oxidative stress, and inflammation. Collectively, Lip-BBR ameliorated diabetic liver injury in a T2DM rat model with its promotion activity of AMPK/mTOR-mediated autophagy and limiting ER stress.
Author Related Publications
Amany Abdalaziz , "Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed", Elseviere, 2022
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Amany Abdalaziz , "Alleviative effects of dietary Indian lotus leaves on heavy metals-induced hepato-renal toxicity, oxidative stress, and histopathological alterations in Nile tilapia, Oreochromis niloticus (L.)", Elsevier B.V., 2019
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Amany Abdalaziz , "Estimation of organochlorine pesticides and heavy metal residues in two species of mostly consumed fish in Sharkia Governorate, Egypt", Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP, 2016
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Amany Abdalaziz , "Comparative protective effects of royal jelly and cod liver oil against neurotoxic impact of tartrazine on male rat pups brain", elsevier, 2015
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Amany Abdalaziz , "Identification of Species Adulteration in Raw Milk and Butter Using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism", IDOSI Publications, 2015
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Department Related Publications
Abdeltawab Mohamed Bahgat , "دراسة تكميلية عن بعض ديدان التريماتودا من اسماك الماء العذب", لايوجد, 1900
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Abdeltawab Mohamed Bahgat , "التاثير المتبادل بين البلهارسيا والسسستيسركس فاشيولارز فى الجرزان البيضاء", لايوجد, 1900
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Mostafa Selem Aboelfotoh, "- Evaluation of Zygomatic Arch Reconstruction using Dexon Mesh and Autogenic Particulate Cancellous Bone and Marrow Graft in Dogs (2004) ", لايوجد, 1900
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Abdallah Alsayed Morssy, "الكشف عن الاجسام المضادة فى الارانب وخنزير غانا المعدية تجريبيا بالديدان الكبدية", لايوجد, 1900
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Abdelmoneim Ahmed Ali Muhmmed, "Nifedipine versus isradipine as antiatherogenic modalities in cholesterol fed rabbits", Zagazig Med.Assoc. J. Vol. 7. No. 1, 1994
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