Intranasal thermosensitive hydrogel of agomelatine solid dispersion for better management of depression

Faculty Pharmacy Year: 2023
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Journal of Drug Delivery Science and Technology Elsevier B.V Volume: Volume 88
Keywords : Intranasal thermosensitive hydrogel , agomelatine solid dispersion    
Abstract:
Agomelatine (AGM) is a unique melatonergic antidepressant drug. However, it possesses low aqueous solubility, first-pass metabolism, and reduced bioavailability. The aim of the current study was to formulate AGM in an intranasal gel to achi
    
     
 
       

Author Related Publications

    Department Related Publications

    • Ahmed Samer Zedan, "Physicochemical characterization and dissolution properties of rofecoxib complexes with cyclodextrins", لايوجد, 1900 More
    • Ahmed Samer Zedan, "Preparation and characterization of rofecoxib solid dispersions with polyethylene glycols and urea", لايوجد, 1900 More
    • Mahmoud Mokhtar AhmedIbrahiem, "Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes", لايوجد, 1900 More
    • Amr Selim Ahmed Ali Abu Lila, "Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration", Elsevier, 2013 More
    • Amr Selim Ahmed Ali Abu Lila, "Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin", Elsevier, 2012 More
    Tweet