Intranasal thermosensitive hydrogel of agomelatine solid dispersion for better management of depression

Faculty Pharmacy Year: 2023
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Journal of Drug Delivery Science and Technology Elsevier B.V Volume: Volume 88
Keywords : Intranasal thermosensitive hydrogel , agomelatine solid dispersion    
Abstract:
Agomelatine (AGM) is a unique melatonergic antidepressant drug. However, it possesses low aqueous solubility, first-pass metabolism, and reduced bioavailability. The aim of the current study was to formulate AGM in an intranasal gel to achi
    
     
 
       

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