Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines

Faculty Pharmacy Year: 2023
Type of Publication: ZU Hosted Pages:
Authors:
Osama Ibrahim Abdou Elsabagh
Journal: ُEuropean Journal of Medicinal Chemistry ُElsevier Volume:
Keywords : Synthesis , , multitarget-directed ligands containing thienopyrimidine nucleus    
Abstract:
A new series of thieno[2,3-d]pyrimidine derivatives 4, 5, 6a-o, and 11 was designed and synthesized starting from cyclohexanone under Gewald condition with the aim to develop multitarget-directed ligands (MTDLs) having anti-inflammatory pro
    
     
 
       

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