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Assessment of the protective and ameliorative impact of quercetin nanoparticles against neuronal damage induced in the hippocampus by acrolein
Faculty
Science
Year:
2024
Type of Publication:
ZU Hosted
Pages:
Authors:
Reham Farouk El Sayed Bayoumi
Staff Zu Site
Abstract In Staff Site
Journal:
Beni-Suef University Journal of Basic and Applied Sciences Springer Nature
Volume:
Keywords :
Assessment , , protective , ameliorative impact , quercetin nanoparticles
Abstract:
Background The most frequent kind of dementia in the senior population is Alzheimer's disease (AD). Antioxidant quercetin has a low bioavailability. The bioavailability of quercetin nanoparticles was demonstrated to be higher. Acrolein is thought to be the strongest unsaturated aldehyde. Acrolein contributes to the propagation of oxidative damage and thus the aetiology of AD. This study aimed to investigate histopathological and ultrastructural changes that may arise in the hippocampus following acrolein treatment. Quercetin nanoparticles' ameliorative and protective effects on acrolein-induced neurotoxicity and oxidative stress were assessed. Results We successfully synthesised quercetin nanoparticles with uniform size distributions and particle diameters in the range of 3.63–4.57 nm using transmission electron microscopy (TEM) and 3.7 nm using dynamic light scattering (DLS). Administration of acrolein was associated with histopathological alterations in the hippocampal structure, such as increased apoptotic neurones, dystrophic changes, neuronophagia, and atrophic ischaemia in cells, as well as marked damage to the ultrastructure of the hippocampus, which was obvious in shrunken pyramidal neurones with pyknotic nuclei and completely degenerated chromatin material, as well as in damaged astrocytes and microglial cells. Treatment with quercetin nanoparticles has been found to protect against and ameliorate the toxic effects and oxidative stress induced by acrolein in the hippocampus. Conclusions This could pave the way for additional research in nanomedicine and a new line of therapeutic intervention in AD using nanoparticles such as quercetin nanoparticles.
Author Related Publications
Reham Farouk El Sayed Bayoumi, "Histopathological studies on the protective and ameliorative role of ginseng extract against epididymal toxicity induced in rats by tartrazine", 12th international conference on civil, agriculture, biological and environment sciences, 2017
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Reham Farouk El Sayed Bayoumi, "The neuroprotective effect of quercetin nanoparticles in the therapy of neuronal damage stimulated by acrolein", Elsevier journals, 2023
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Reham Farouk El Sayed Bayoumi, "Assessment of the Protective and Ameliorative Role of Quercetin Nanoparticles against Histopathological Changes Induced in the Cerebral Cortex of Rats by Acrolein", bulletin of faculty of science zagazig university, 2023
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Department Related Publications
Reham Zakaria Mustafa Mohammed Hamza, "Hyperglycemic effect of Chlorpyrifos , Profenofos and possible ameliorative role of Propolis and ginseng", Scientia Agriculturae© PSCI Publications, 2014
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Iman Hassan Mohammed Sheikh, "Ultramorphological and histological studies on the tongue of the common kingfisher in relation to its feeding", Elsevier, 2014
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Reham Zakaria Mustafa Mohammed Hamza, "Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat", De Gruter, 2014
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Kamel Zaki Hamid, "Microsatellite Chromosomal Instability in Bladder Cancer Patients Infected with Hepatitis C Virus", Intern J Sci Res, 2014
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Abeer Samir Mohammed Yamani, "استخدام المسح الإلكترونى الميكروسكوبى لدراسة مورفولوجيا السطح و القياس المترى للسطح الخارجى لبعوضة Culex pipiens pipiens و Culex quinquefasciatus ( ثنائية الأجنحة : كيوليسيدى )", Journal of the Egyptian Society of Parasitology, 2015
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