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The neuroprotective effect of quercetin nanoparticles in the therapy of neuronal damage stimulated by acrolein
Faculty
Science
Year:
2023
Type of Publication:
ZU Hosted
Pages:
Authors:
Reham Farouk El Sayed Bayoumi
Staff Zu Site
Abstract In Staff Site
Journal:
Saudi Journal of Biological Sciences Elsevier journals
Volume:
Keywords :
, neuroprotective effect , quercetin nanoparticles , , therapy , neuronal
Abstract:
A gradual loss of neuronal function or structure causes neurodegenerative disorders such as Parkinson's and Alzheimer's. Neurological damage might cause cell death. Acrolein is a high-risk air and water contaminant that causes neurodegenerative disorders. Quercetin has several strategies for treating neurodegenerative disorders but has limited bioavailability inside the body. One of the hypotheses offered to improve quercetin's bioavailability is to convert it into quercetin nanoparticles. This study aims to comprehend the immunohistochemical devastation that might arise in the cerebellum because of acrolein treatment. Furthermore, the protective and ameliorative roles of quercetin nanoparticles against oxidative stress and neurotoxicity induced in mice by acrolein were assessed. Ninety male albino rats weighing 120 to 200 g were used in the present investigation. The animals were split up into the following six groups: the control group, the acrolein-treated group: animals were given acrolein (3 mg/kg) for 30 days, quercetin nanoparticles treated group: animals were given quercetin nanoparticles (30 mg/kg) for 30 days. The administration of acrolein was found to be connected to immunohistochemical abnormalities in the cerebellum. Marked differences were observed in Bax, Bcl-2, TNF-α, and GFAP expressions in the cerebellum. Treatment of rats with quercetin nanoparticles either before or after treatment with acrolein has been found to preserve the cerebellum tissues from the toxic impacts and oxidative stress induced by acrolein. This may open the door to more nanomedicine studies and a new avenue for employing nanoparticles as a therapeutic intervention in neurodegenerative illnesses.
Author Related Publications
Reham Farouk El Sayed Bayoumi, "Histopathological studies on the protective and ameliorative role of ginseng extract against epididymal toxicity induced in rats by tartrazine", 12th international conference on civil, agriculture, biological and environment sciences, 2017
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Reham Farouk El Sayed Bayoumi, "Assessment of the protective and ameliorative impact of quercetin nanoparticles against neuronal damage induced in the hippocampus by acrolein", Springer Nature, 2024
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Reham Farouk El Sayed Bayoumi, "Assessment of the Protective and Ameliorative Role of Quercetin Nanoparticles against Histopathological Changes Induced in the Cerebral Cortex of Rats by Acrolein", bulletin of faculty of science zagazig university, 2023
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Department Related Publications
Samir Abdullah Taha, "Comparative toxicity of Paraquat herbicide and some plant extracts in Lymnaea natalensis snails", كلية العلوم, 2013
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Wageha Abdullah Ibrahim Mustafa, "Pathogenicity of entomopathogenic fungi on larvae of Culex pipiens mpsquitoes (Diptera : Culicidae)", (American-Eurasian Network for Scientific Information (AESNI, 2013
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Susan Attia Moawad, "A Comparative Morphological and Histological Study of the Olfactory Organ in Two Models of Bony Fishes (Mugil cephalus and Malapterurus electricus): A light and Electron microscopic study.", مجلة كلية العلوم, 2013
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Iman Hassan Mohammed Sheikh, "Light and scanning electron microscopic study of the dorsal lingual papillae of the rat Arvicanthis niloticus (Muridae, Rodentia)", Elsevier, 2012
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Iman Hassan Mohammed Sheikh, "Scanning Electron Microscopic Studies of Gill Arches and Rakers in Relation to Feeding Habits of Some Fresh Water Fishes", Elsevier, 2013
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