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Physiological and metabolic traits of Taxol biosynthesis of endophytic fungi inhabiting plants: Plant-microbial crosstalk, and epigenetic regulators
Faculty
Science
Year:
2023
Type of Publication:
ZU Hosted
Pages:
127385
Authors:
Nabil zakaria mohamed elsayed
Staff Zu Site
Abstract In Staff Site
Journal:
Microbiological Research Elsevier
Volume:
Keywords :
Physiological , metabolic traits , Taxol biosynthesis , endophytic
Abstract:
Attenuating the Taxol productivity of fungi with the subculturing and storage under axenic conditions is the challenge that halts the feasibility of fungi to be an industrial platform for Taxol production. This successive weakening of Taxol productivity by fungi could be attributed to the epigenetic down-regulation and molecular silencing of most of the gene clusters encoding Taxol biosynthetic enzymes. Thus, exploring the epigenetic regulating mechanisms controlling the molecular machinery of Taxol biosynthesis could be an alternative prospective technology to conquer the lower accessibility of Taxol by the potent fungi. The current review focuses on discussing the different molecular approaches, epigenetic regulators, transcriptional factors, metabolic manipulators, microbial communications and microbial cross-talking approaches on restoring and enhancing the Taxol biosynthetic potency of fungi to be industrial platform for Taxol production.
Author Related Publications
Nabil zakaria mohamed elsayed, "Microbial cytosine deaminase is a programmable anticancer prodrug mediating enzyme: antibody, and gene directed enzyme prodrug therapy", Elsevier, 2022
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Nabil zakaria mohamed elsayed, "Induction of Taxol biosynthesis by Aspergillus terreus, endophyte of Podocarpus gracilior Pilger, upon intimate interaction with the plant endogenous microbes.", El SEVIER, 2018
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Nabil zakaria mohamed elsayed, "Restoring the Taxol biosynthetic machinery of Aspergillus terreus by Podocarpus gracilior Pilger microbiome, with retrieving the ribosome biogenesis proteins of WD40 superfamily", nature, 2019
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Nabil zakaria mohamed elsayed, "Phytochemical and metabolic profiling of the different Podocarpus species in Egypt: Potential antimicrobial and antiproliferative activities", Elsevier, 2023
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Nabil zakaria mohamed elsayed, "Aspergillus niger thermostable Cytosine deaminase-dextran conjugates with enhanced structure stability, proteolytic resistance, and Antiproliferative activity.", Springer, 2023
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Department Related Publications
Tamer Aly Elsayed Sweilem, "تأثير البرولين و حامض السالسليك و قش الأرز على نمو و انتاجية نبات الفول البلدي المنزرع تحت ظروف الجفاف", كلية العلوم - جامعة الزقازيق, 2013
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Mohamed Farouk Ibrahim Aly, "T HE RELATIONSHIP BETWEEN SALTS AND GROWTH OF STREPTOMYCES COLONIES ISOLATED FROM MURAL PAINTINGS IN ANCIENT EGYPTIAN TOMBS", كلية العلوم جامعة الزقازيق, 2013
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weSam AbelGhani Aly, "Fibrinolysis and anticoagulant potential of a metallo protease produced by Bacillus subtilis K42", Indian Academy of Sciences, 2011
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weSam AbelGhani Aly, "Molecular and microbiological studies on vancomycin resistant Staphylococcus aureus (VRSA) strains isolated from burned patients", .egypt. j. exp.biot. bot, 2013
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weSam AbelGhani Aly, "The Antagonistic Activities of Some Metabolites Produced by Pseudomonas aeruginosa Sha8", , INSInet Publication, 2009
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