Background: Information technology (IT) increases the work proficiency of the nurses that helps to enhance the patients' well-being which includes reducing of medication errors and benefiting the health care organizations. Aim: The current study aims to determine the impact of information technology that improves nurses' work outcomes and suggesting strategies to generalize IT utilization in other health care facilities in Egypt. Methods: A descriptive methodological design is utilized with three different samples are used for analysis as follows; 250 nursing staff from the oncology center in Mansoura university hospital, 394 nurses through a web-based survey and a Jury committee. Three scales are utilized in the study: information technology scale, nurses' work outcome factors questionnaire, and other tools to measure barriers and challenges of generalizing IT utilization in other health care facilities in Egypt. Results: The highest benefits of IT in health care facilities were stress-free communication and documentation. A high mean score of productivity and performance related to nurse's work outcome factors were observed. The first barrier to using IT is related to resistance to change, then no motivated staff to use the new IT and budget allocated for IT utilization in the workplace is not enough (96.2;95.2;94.4 %) respectively. Conclusion: There is a correlation between all the dimensions of IT and nurses' work outcome factors in the study. Nursing staff that using information technology will be improve nurses work outcome. Recommendations: applied and practiced suggested strategies to overcome barriers to generalization information technologies (IT) utilization in other health care facilities in Egypt. Decision-making provision of IT implementation is an essential stage near highlighting IT scopes in a hospital.