Abstract: Background: This study adds to the international debate about the relationship between job satisfaction, non-nursing tasks and nursing tasks left undone and by assessing the variables at practical nurses and hospital unit level. This research aimed to explore the relationship between job satisfaction, non-nursing tasks and nursing tasks left undone among nurses at Zagazig University hospitals in Egypt. Subject and methods: A descriptive methodological design was used. The sample size was (320) staff nurses. A self-administered survey questionnaire was used to collect data used for this research, which includes four parts; (1) Demographic characteristics of the nurses; (2) Job satisfaction survey; (3) non-nursing tasks scale; (4) Nursing tasks left undone scale. Results: more than half of the nurses were neutral meanwhile there was a low level of nurse job satisfaction. five non-nursing tasks were greatest frequently conducted by the studied nurses. There were nursing tasks left undone by the studied nurses. There was no a statistically significant difference between the studied nurses' job satisfaction and their work in non–nursing tasks, along with nurses' job satisfaction, and their tasks left undone. Conclusions: nurses were less satisfied with their job; the nurses often perform non-nursing tasks and leave some essential nursing tasks undone. there was a high statistically significant positive correlation between studied nurses' non– nursing tasks, and their nursing tasks left undone. While there were no significant correlations between studied nurses' job satisfaction, and their non–nursing tasks, into the bargain; nurses' job satisfaction, and their nursing tasks were left undone. Recommendation: Nurse managers at Zagazig University Hospitals should develop and implement strategies to improve job satisfaction levels for nurses. Work environments should be structured to minimize nurses' performance of non-nursing tasks; this is in the form of allocating adequate and efficient support services to get rid of their workload. This in turn decreases the frequency of nursing tasks left undone by them. Keywords: infection controls, COVID-19 patients, health care workers. Keyword: Nurses, job satisfaction, non-nursing tasks, Nursing tasks left undone.