Background: Achievement motivation is prerequisite for achievement to succeed and to perform well in relation to a standard of excellence. Motivation is the driving force behind all the actions of an individual. The aim: of study was to assess the effect of achievement motivational training program on self-efficacy among nursing students. Materials and Methods: Quasi-experimental design was conducted at Faculty of Nursing – Kafr-elshiekh University, Study sample: Simple random sample of the fourth year nursing students their total number were 100. Two tools were used for data collection namely; the achievement motivation questionnaire & self-efficacy questionnaire. Results: before the program implementation the nursing student had low level achievement motivation, and low level self-efficacy (62%,98%) however after program implementation the highest percentage of them have high level of achievement motivation and high level of self-efficacy (96%, 52 %) . Conclusion: there was statistically significant improvement in nursing student achievement motivation and subsequently increase self-efficacy among nursing students. In addition to, there was no statistically significant relation between nursing students' personal characteristics and both of achievement motivation, self-efficacy.Recommendation: Nursing teaching staff should provide support for their students and should explain the real motive behind an academic task, encourage students to talk about their future planning including career and personnel goals. Nursing teaching staff should be boosts up student’s level of confidence and morale through persistent encouragement and provide guidance.