The flavonoid hesperidin methyl chalcone as a potential therapeutic agent for cancer therapy: Molecular docking, in vitro cytotoxicity, and in vivo antitumor activity

Faculty Pharmacy Year: 2023
Type of Publication: ZU Hosted Pages:
Authors:
Amr Selim Ahmed Ali Abu Lila
Journal: Arabian Journal of Chemistry ELSEVIER Volume:
Keywords : , flavonoid hesperidin methyl chalcone , a potential therapeutic    
Abstract:
Hesperidin methyl chalcone (HMC) is a methylation product of the flavanone hesperidin, a flavonoid derived from citrus fruits. Many reports have emphasized the analgesic, antiinflammatory and antioxidant properties of HMC. However, the anticancer potential of HMC has not been fully elucidated. The objective of this study was to assess the possible anticancer potential of HMC. MTT assay was carried out to assess the in vitro cytotoxicity of HMC against using A549 cancer cell line. In addition, the in vivo antitumor activity of HMC was screened against murine Ehrlich ascites carcinoma (EAC) model, in terms of tumor volume, tumor weight, life span,
    
     
 
       

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  • Nagia] Ahmed Alameen Elmgrab, "Buccoadhesive Tablets for Delivery of Tramadol Hcl: Design and In Vitro Analysis", University of Alexanderia faculty of pharmacy, 2006 More
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