Background: Preoperative anxiety in children is highly prevalent, associated with negative outcomes, and has the potential to alter the dynamics of a surgical operation. If preoperative anxiety is mismanaged, it can result in postponed or canceled essential procedures. Objective: The study aimed to investigate whether self-driving of children to an operating room could relieve their preoperative anxiety and pain, in addition to assessing parental satisfaction. Methods: A prospective, two-armed quasi-experimental study was designed with three measurement time points, including 60 children (4-10 years) from both genders who had undergone elective surgeries and who were randomly allocated to the study group (n = 30) and control group (n = 30). Both groups received standard information provided by the nursing staff, and the study group only used self-driving to the operating room. The primary outcome was change in the children preoperative anxiety levels, as measured by the modified Yale Preoperative Anxiety Scale (m-YPAS) and the measurement of the physiological variables both in ward and when the children approached the anesthesia room. Pain was assessed by the Faces Pain Scale-Revised (FPS-R). A secondary outcome was parent satisfaction. Results: The study and control groups were homogeneous with regard to age (P-value = .498) and gender (P-value = .292). No significant difference in anxiety level was observed between the study and control groups at the baseline (T1) (P-value = .057). Differences were detected between both groups during intervention—while the children drove themselves to the OR (T2) and in the pre-surgical area (T3)—and these differences were statistically significant (p<0.000). The mean parental satisfaction score of the study group was higher than the mean scores of the control group and the difference was statistically significant. Conclusion: Children’s self-driving to the operating room was effective in reducing preoperative anxiety in children aged 4 to 10 years and could potentially be offered to most children as a low-cost, easy to implement, and effective approach to relieving anxiety in the preoperative area.