Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

Faculty Pharmacy Year: 2022
Type of Publication: ZU Hosted Pages: 203-215
Authors:
Osama Ibrahim Abdou Elsabagh
Journal: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Taylor & Francis Group Volume:
Keywords : Design, synthesis , antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines    
Abstract:
The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifola
    
     
 
       

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