Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

Faculty Pharmacy Year: 2022
Type of Publication: ZU Hosted Pages: 203-215
Authors:
Osama Ibrahim Abdou Elsabagh
Journal: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Taylor & Francis Group Volume:
Keywords : Design, synthesis , antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines    
Abstract:
The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifola
    
     
 
       

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  • Osama Ibrahim Abdou Elsabagh, "Synthesis and Biological Evaluation of Some N-Arylpyrazoles and Pyrazolo[3,4-d]pyridazines as Anti-Inflammatory Agents", 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2013 More
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  • Osama Ibrahim Abdou Elsabagh, "Synthesis and pharmacological studies for some new benzotriazole and dibenzodiazepine derivatives as antipsychotic agents", KOREAN CHEMICAL SOC, 2009 More
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Department Related Publications

  • Etedaal Hassan Mohamed Abdulaal, "18. In situ annelation of enaminones by reaction with methyleneiminium intermediates", لايوجد, 1900 More
  • Hanan Abdelraziek Abdelfattah Ali Hamied, "synthesis of some new imidazolones of expected antimicrobial activity", لايوجد, 1900 More
  • Azza Mohamed Kadry , "35. Synthesis and potentiometric study of some dioxadiaza ionophores in ion selective electrodes", لايوجد, 1900 More
  • Azza Mohamed Kadry , "16. Chemistry of quinazolines: Reinvestigation of the action of hydrazine on thioxo derivatives", لايوجد, 1900 More
  • Azza Mohamed Kadry , "2. Reaction and rearrangement of 2,4-quinazolinediones", لايوجد, 1900 More
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