Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

Faculty Pharmacy Year: 2022
Type of Publication: ZU Hosted Pages: 203-215
Authors:
Osama Ibrahim Abdou Elsabagh
Journal: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Taylor & Francis Group Volume:
Keywords : Design, synthesis , antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines    
Abstract:
The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifola
    
     
 
       

Author Related Publications

  • Osama Ibrahim Abdou Elsabagh, "Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium", 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2013 More
  • Osama Ibrahim Abdou Elsabagh, "Synthesis and Biological Evaluation of Some N-Arylpyrazoles and Pyrazolo[3,4-d]pyridazines as Anti-Inflammatory Agents", 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2013 More
  • Osama Ibrahim Abdou Elsabagh, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer, 2012 More
  • Osama Ibrahim Abdou Elsabagh, "Synthesis and pharmacological studies for some new benzotriazole and dibenzodiazepine derivatives as antipsychotic agents", KOREAN CHEMICAL SOC, 2009 More
  • Osama Ibrahim Abdou Elsabagh, "Synthesis and antiviral activity of new pyrazole and thiazole derivatives", Elsevier Masson SAS., 2009 More

Department Related Publications

  • Alaa Nabil Hassan Mustafa Ouf, "SYNTHESIS OF NEW PYRIMIDINE DERIVATIVES AND EVALUATION OF THEIR ANTICANCER AND ANTIMICROBIAL ACTIVITIES", Asian J Pharm Clin Res, 2016 More
  • Hanan Abdelraziek Abdelfattah Ali Hamied, "تشييد مشتقات الايميدازول والايميدازول الملتحمة الجديدة كمضادات للسرطان والميكروبات : والنمذجة جزئية للمركبات والتقييم البيولجي", الهند, 2015 More
  • Zakareyah Kamel Abdelsamie, "New routes to heterocycles via sulphenylation of unsaturated amides", Tetrahedron Letters, 1987 More
  • Zakareyah Kamel Abdelsamie, "Synthesis and antibacterial activity of of some 1,3,4,-oxadiazoles", Mans. J. Pharm. Sci, 1991 More
  • Nermeen Awny Ahmed Mohamd, "Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages", Elsevier Inc., 2022 More
Tweet