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Chemical profiles with cardioprotective and antidepressive effects of Morus macroura Miq. leaves and stem branches dichloromethane fractions on isoprenaline induced post-MI depression†
Faculty
Pharmacy
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Wafaa Hassan Badr Hassan
Staff Zu Site
Abstract In Staff Site
Journal:
RSC Advances Royal society of chemistry
Volume:
Keywords :
Chemical profiles with cardioprotective , antidepressive effects , Morus
Abstract:
This study was conducted to explore the potential cardioprotective and anti-depressive effects of dichloromethane (DCM) fractions of Morus macroura leaves (L) and stem branches (S) on postmyocardial infarction (MI) depression induced by isoprenaline (ISO) in rats in relation to their metabolites. The study was propped with a UPLC-ESI-MS/MS profiling and chromatographic isolation of the secondary metabolites. Column chromatography revealed the isolation of lupeol palmitate (6) that was isolated for the first time from nature with eight known compounds. In addition, more than forty metabolites belonging, mainly to flavonoids, and anthocyanins groups were identified. The rats were injected with ISO (85 mg kg 1 , s.c) in the first two days, followed by the administration of M. macroura DCM-L and DCM-S fractions (200 mg kg 1 p.o) for 19 days. Compared with the ISO exposed rats, the treated rats displayed a reduction in cardiac biomarkers (LDH and CKMB), anxiety, and depressive-like behaviour associated with an increase in the brain defense system (SOD and GSH), neuronal cell energy, GABA, serotonin, and dopamine, confirmed by histopathological investigations. In conclusion, DCM-L and DCM-S fractions' cardioprotective and anti-depressive activities are attributed to their metabolite profile. Therefore, they could serve as a potential agent in amending post-MI depression.
Author Related Publications
Wafaa Hassan Badr Hassan, "NOVEL PROPENYL FLAVONOIDS GLYCOSIDE AND ANTIOXIDANT ACTIVITY OF EGYPTIAN BAUHINIA RETUSA", International Journal of Pharmaceutical Sciences and Research, 2014
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Wafaa Hassan Badr Hassan, "MACRO- AND MICROMORPHOLOGICAL STUDY OF DAUCUS CAPILLIFOLIUS GILLI CULTIVATED IN EGYPT", European Journal of Pharmaceutical and Medical Research, 2018
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Wafaa Hassan Badr Hassan, "Chemical Composition and Biological Activities of the Aqueous Fraction of Parkinsonea aculeata L. Growing in Saudi Arabia", ُُElsevier, 2018
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Wafaa Hassan Badr Hassan, "Anticancer activity and concurrent analysis of ursolic acid, b-sitosterol and lupeol in three different Hibiscus species (aerial parts) by validated HPTLC method", Elsevier, 2018
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Wafaa Hassan Badr Hassan, "Concurrent analysis of bioactive triterpenes oleanolic acid and b-amyrin in antioxidant active fractions of Hibiscus calyphyllus, Hibiscus deflersii and Hibiscus micranthus grown in Saudi Arabia by applying validated HPTLC method", Elsevier, 2017
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Department Related Publications
Ehsan Mahmoud Abdelaziz Abozied, "Pharmacognostical study and phytochemical investigation of launaea mucronata ", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "7) GC-MS and Antimicrobial Activity of Volatile Oil of Apium Leptophyllum (Benth). ", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "17) Phytochemical study and Bioassay of some constituents from Heliotropium Bacciferum Forssk", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "27) Phytochemical and Biological studies of the shells of Arachis hypogae L. Fruits (Pea Nut) Cutivated in Egypt", لايوجد, 1900
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Ehsan Mahmoud Abdelaziz Abozied, "18) Macro- and Micromorphology of the Leaf, Stem & Root of Heliotropium bacciferum (Forsk). ", لايوجد, 1900
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