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β-Cell Autophagy Pathway and Endoplasmic Reticulum Stress Regulating-Role of Liposomal Curcumin in Experimental Diabetes Mellitus: A Molecular and Morphometric Study
Faculty
Veterinary Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Amany Abdalaziz
Staff Zu Site
Abstract In Staff Site
Journal:
Antioxidants MDPI
Volume:
Keywords :
β-Cell Autophagy Pathway , Endoplasmic Reticulum Stress
Abstract:
Abstract: Background: Autophagy can confer protection to pancreatic -cells from the harmful effects of metabolic stress by delaying apoptosis. Curcumin (CUR) alleviates oxidative and endoplasmic reticulum (ER) stress, activates autophagy, reduces inflammation, and decreases -cell damage in type I diabetes. Liposomal CUR (LPs-CUR) has a higher therapeutic value and better pharmacokinetics than CUR. Objectives: We determined LPs-CUR’s ability to alleviate stress, reduce -cell damage and unraveled the mechanism underlying its protective effect using a streptozotocin (STZ)-induced type I diabetic rat model. Methods: Sprague–Dawley rats were grouped into vehicle control, STZdiabetic (STZ 65 mg/kg), STZ-diabetic-3-MA (3-methyladenine [3-MA] 10 mg/kg b.wt), STZ. diabetic- LPs-CUR (LPs-CUR 10 mg/kg b.wt), and STZ diabetic-LPs-CUR-3-MA (LPs-CUR 10 mg/kg b.wt; 3-MA 10 mg/kg b.wt). Results: LPs-CUR significantly reduced blood glucose, oxidative stress, and cellular inflammation in the pancreatic tissue (p < 0.001). ER stress-dependent genes included ATF-6, eIF-2, CHOP, JNK, BiP, and XBP LPs-CUR significantly suppressed fold changes, while it upregulated the autophagic markers Beclin-1 and LC3-II. Conclusions: LP-CUR ameliorates -cell damage by targeting the autophagy pathway with the regulatory miRNAs miR-137 and miR-29b, which functionally abrogates ER stress in -cells. This study presents a new therapeutic target for managing type I diabetes using miR-137 and miR-29b.
Author Related Publications
Amany Abdalaziz , "Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed", Elseviere, 2022
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Amany Abdalaziz , "Alleviative effects of dietary Indian lotus leaves on heavy metals-induced hepato-renal toxicity, oxidative stress, and histopathological alterations in Nile tilapia, Oreochromis niloticus (L.)", Elsevier B.V., 2019
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Amany Abdalaziz , "Estimation of organochlorine pesticides and heavy metal residues in two species of mostly consumed fish in Sharkia Governorate, Egypt", Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP, 2016
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Amany Abdalaziz , "Comparative protective effects of royal jelly and cod liver oil against neurotoxic impact of tartrazine on male rat pups brain", elsevier, 2015
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Amany Abdalaziz , "Identification of Species Adulteration in Raw Milk and Butter Using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism", IDOSI Publications, 2015
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Hussein Ibrahim Hussin Elbelbesy , "The impact of staphylococcal mastitis on the level of milk IL-6 lysozyme and nitric oxide. ", لايوجد, 1900
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