The talus, also called astragalus bone, is a small, irregular bone that sits on top of the other bones of the foot. It is the only bony connection between the tibia, fibula, and the other tarsal bones. Despite its small size, it is a dense and strong bone. It transfers the weight of the human body through the tibia to the foot. Reviewing the anatomy of talus is essential for physicians and orthopedic surgeons for proper diagnosis and management of any disorder involving the ankle. This is because the talus is involved in many joints that can affect human movements in walking, running and even standing properly. In this short review, we will focus on some of the unique anatomical features of talus that may assist clinicians in their clinical practice. The unique feature of the ankle is that most of its surface is covered with articular cartilage. In addition, there are no muscles attached to the bone. This may be a cause of poor blood flow to the talus and may lead to poor healing after a fracture.