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Metabolite Profiling of Date Palm Fruit (Phoenix dactylifera L.) And Its Cytoprotective Effects Versus Vitamin C Against Mobile Phone Radiation-Induced Adrenal Gland Damage In Rats
Faculty
Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Rasha Mohamed Sabry
Staff Zu Site
Abstract In Staff Site
Journal:
zagazig university medical journal zagazig university
Volume:
Keywords :
Metabolite Profiling , Date Palm Fruit (Phoenix
Abstract:
Background: Date palm fruit (Phoenix dactylifera L.) can be used as a pharmaceutical product because of its rich phytochemical composition. Mobile phone radiation is a type of electromagnetic radiation (EMR) that has been confirmed to exert several adverse effects on living tissues. Methods: In this study, we investigated the phytochemicals of the Egyptian date palm fruit using ultra-performance liquid chromatography with electrospray ionization quadrupole- linear ion trap tandem mass spectrometry analysis (UPLC-ESI-MS/MS) in negative and positive ionization modes. Adult male Wister albino rats were exposed to mobile phone induced electromagnetic radiations (EMR) for 1 hour per day for 4 weeks. We evaluated the possible cytoprotective effects of date palm fruits compared with vitamin C on mobile phone induced EMR. Rats were divided into the control, EMR, and two EMR groups treated with either vitamin C or date palm fruit. Results: The analysis of date resulted in the tentative identification of 29 compounds, including 13 free organic acids and their derivatives, 9 flavonoids and their glycosides, 3 fatty acids, and 4 miscellaneous compounds. Both biochemical and histopathological examinations of adrenal tissues confirmed that mobile phone radiation caused significant increases in oxidative stress, DNA damage, inflammatory marker levels, fibrosis, and apoptosis in adrenal tissues compared with the control group. Both vitamin C and date palm fruit significantly reduced these damaging effects with superior cytoprotective effect for date palm fruit over vitamin C. Conclusion: Date palm fruits could protect the adrenal glands due to its antiapoptotic, antioxidant, antifibrotic and anti-inflammatory properties. Keywords: Date palm fruit (Phoenix dactylifera L); UPLC-ESI-MS/MS; Adrenal gland; Mobile (cell) phone radiation; Tumor necrosis factor α.
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Department Related Publications
Rasha Mohamed Sabry, "Efficacy of olibanum and propolis medicinal extracts versus metronidazole in Giardia lamblia experimentally infected mice", zagazig university, 2020
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Rasha Mohamed Sabry, "Protective Effect of Date Palm Fruits (Phoenix Dactylifera L.) versus Vitamin C Against Mobile Phone Radiation-induced Pituitary Gland Damage in Rats", Zagazig University, 2022
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Rasha Mohamed Sabry, "Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt/β-arrestin2/ β-catenin pathway", elsevier, 2022
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