Background: The success of any organization is highly dependent on how it attracts recruits, motivates and retains its workforce. Therefore, organizations are required to adopt a strategy that improves the employees’ quality of work life to satisfy both the organizational objectives and employee needs. Employee engagement and spiritual intelligence are important concepts to consider when dealing with changes at work and improving performance. Aim: Was to assess the relationship between spiritual intelligence, work engagement with the quality of work life among nurses at Zagazig University Hospitals .Study design: A descriptive co-relational study design was used. Setting: study was conducted at all Zagazig University Hospitals (Academic hospital), Egypt. Study subjects: A stratified random sample was used. 384 nurses were chosen from the above mentioned setting. Tools of data collection: Data were collected using a questionnaire sheet for staff nurses composed of four parts: Personal characteristics, self-assessment questionnaire of spiritual intelligence, The Utrecht Work Engagement Scale (UWES) and Survey of quality of work life to measure quality of work life among nurses. Results: Revealed that 74.5% of staff nurses have moderate quality of work life, while 95.3% and 82.6% of them had high spiritual intelligence and work engagement respectively with all domains. Conclusion: There was a statistically significant difference between all dimensions of work engagement, spiritual intelligence and quality of work life. Therefore, it is recommended: to develop a fair reward system that includes financial and non financial rewards ,reducing the feeling of nervousness, strain, frustration, and stress at work for augmenting the perceived quality of work life and enhance nurse’s spiritual intelligence by encouraging them to share in problems solving and taking decision, and provide adequate help and support, multi-disciplinary interventions to improve nurses' quality of work life need to be developed, implemented, and their effectiveness assessed.