Introduction: The parental role is crucial in the management of child’s seizures before, during, and after the fits. They also have an important role in the process of decision-making about the choice of treatment modality for their children, and in planning for a holistic care for them encompassing all social and psychological aspects. In order to be able to fulfil this role effectively, caregiving parents need to know the etiology of the disease and its effect on the child as well as the caregiver him/herself. This would also enhance their self-efficacy in dealing with their children’s illness, which is a key element in Bandura’s Social Cognitive Theory. In fact, the caregivers with high self-efficacy are more able to achieve caregiving tasks at the best level, with less psycho-social stress, fatigue, and tensions. However, parents’ learning needs are often not fulfilled. Epilepsy is a common problem in childhood with high burden on caregivers given the unpredictable fits, and associated comorbid conditions. Education and training are essential in helping these caregivers to cope with the situation and provide good caregiving through improving their knowledge, attitude, skills, and self-efficacy. Aim of study This study was conducted to assess the effect of an educational intervention on the knowledge, attitude, reported practice and self-efficacy of caregivers of children with epilepsy. Research design: A one-group quasi-experimental design was used. Setting: pediatrics outpatient clinics affiliated to Al-Ahrar - Zagazig Teaching Hospital. Study subjects: 60 caregivers accompanying their children suffering from epilepsy and receiving treatment in the study settings. Tools of data collection: A structured self-administered questionnaire sheet It comprised six parts. The (1st part) was for caregiver socio-demographic characteristics, the (2nd) part covered epileptic child bio-data. The (3rd) part was for assessing caregivers’ knowledge of epilepsy. The (4th) part of the questionnaire measured caregiver’s attitude. The (5th) part of the questionnaire was intended to assess caregiver’s reported practice while caring for the epileptic child. The (6th) part of the tool measured caregiver’s self-efficacy using the “Revised Scale for Caregiving Self-Efficacy”. Results revealed that: The caregivers in the study sample were mostly mothers (86.7%), with a mean age of 31.3 years. The majority were married (83.8%), not working (75.0%), and with insufficient income (66.7%). the age of children was mostly below four years (56.7%). Most of these children were second in birth order rank (46.7%), The fits mostly occurred 3-5 times per month (81.7%) and lasted 3-5 minutes (61.7%), preceded by precipitating factors (71.7%). Only 36.7% of the children were compliant with treatment, and an almost equal percentage (33.0%) improved on treatment. The impact of epilepsy on relationships was less within the family (18.3%) compared to outside (78.3%). The results reveal generally low scores of caregivers’ knowledge, attitudes, and reported practices in all its tested areas at the pre-intervention phase. The mean of the knowledge score at the pre-intervention phase (23.65) was less than half of the maximum attainable score of 50.0. The post-intervention scores of knowledge, attitude, and reported practice demonstrated statistically significant improvements (p<0.001). This was noticed in all areas as well as in total scores. The mean total scores of knowledge and practice almost doubled (p<0.001). Meanwhile the result reported low scores were noticed in all three aspects of self-efficacy as well as its total before the intervention, with the total mean score being less than a half of the maximum attainable score of 45.0. Meanwhile, statistically significant improvements were shown at the post-intervention phase in all areas of self-efficacy. The total mean score increased from 22.08 to 34.20 (p<0.001). Conclusion: The educational program was a significant independent positive predictor of caregivers’ scores of knowledge, attitudes, practice and self-efficacy, which reflects the importance of providing educational intervention to improve the knowledge, attitude, practice, and self-efficacy of the caregivers of epilepsy children. Based on the findings of this study, the following recommendations are suggested: To assure the sustainability of the educational intervention effect, it is recommended to make reassessment over a long-time plan utilizing the time-series design. On the other hand, random sampling constitutes one of the major threats and limitations to the study findings, therefore, it is recommended to implement the study on random caregiver samples with the inclusion of hospitals from other governorates in Egypt.